Protestant attacks against papal corruption of the cult of saints and falsification of miracles led the Post-Tridentine Church to reform the processes of saint-making through an intensified collaboration with medical science. The alignment of faith and science at the nexus of the human body culminated in the eighteenth century under Benedict XIV Lambertini (r. 1740–58). Benedict published a monumental treatise, still influential today, that codified canonization proceedings on the basis of modern medical expertise, and he was a preeminent patron of scientific and medical institutions and practitioners for the advancement of medical knowledge and public health. The imperatives of the Counter-Reformation, canon law, experimental science and medicine, and the burgeoning Enlightenment coalesced, albeit uneasily, in his vision of a reformed Church, for which natural and saintly bodies became primary emblems in defense of the authority of the Catholic Church in a world increasingly resistant to it.

In recent years, the history of emotions has acquired an epistemological maturity that has established its legitimacy in the historiographic field. But what is an emotion? Although "emotion" is not a medieval word, the great historian of emotions, Barbara H. Rosenwein, refuses the semantic fixity of the vocables, by slipping voluntarily on the terms and by the playing of the synonymies. Emotional expressionism is the mark of the late Middle Ages in religious life but also in the political, ecclesial, and social worlds. The social sharing of emotions fulfills the function of strengthening the collective identity. In a sense, to rewrite the history of the Great Schism from the perspective of the history of emotions is to consider the great fresco of ecclesiastical passions in their experiences, their discursivity, and their subsequent reception. Passions were often silenced a posteriori by the great official narrative of the Church. That is the gap between archives and narratives.

Not a day goes by without a new story on the perils of technology. We hear of increasingly clever machines that surpass human capability and comprehension, of tech billionaires imploring each other to stop the ‘out-of-control race’ to produce the most powerful artificial intelligence which poses ‘profound risks to society’, we hear of genetic technologies capable of altering the human genome in ways we cannot predict and a future two-tier humanity consisting of those of us who are genetically enhanced and those who are not. How can we respond to these stories? What should we do politically? By way of exploring these questions (using the UK as the primary example of context), I want to move beyond the usual arguments and legal devices that serve to identify tech developers, and users, as being at fault for individual acts of wrongdoing, recklessness, incompetence or negligence, and ask instead how we might address the broader structural dynamics intertwined with the increasing use of AI and Repro-tech. My argument will be that to take a much sharper structural perspective on these transformative technologies is a vital requirement of contemporary politics.

Brain immune privilege for many years overshadowed investigation of interaction between the nervous and immune systems. Over time, however, evidence of their interdependence has emerged. In the 1970s, as antibody-mediated autoimmunity was being defined, the neurological disorder myasthenia gravis was shown to be due to autoantibodies that could be passively transferred to mice and removed from humans by plasma exchange. In the 1980s, Fink and Weihe showed that neurons innervate lymph nodes, and from the 1990s onwards, Rothwell and colleagues observed the impact of soluble inflammatory mediators on behaviour. For example, in a key experiment, her team showed that systemic and intraventricular injection of IL-1 led to fever and reduced food motivation in experimental animals, interpreted as “sickness behaviour”; this technique is now used as a model for inflammation-driven depression. Furthermore, IFN- α was unexpectedly found to cause depression when given as a treatment for hepatitis C. More recently, diseases have been identified in which autoantibodies interfere with neuronal function and cause severe psychiatric symptoms, such as N-Methyl D-Aspartate Receptor (NMDAR)-antibody encephalitis. There is now emerging interest in the patho-aetiological role of the immune system in various severe mental illnesses, and the use of immunotherapies in their treatment.

Archdeacon Hildebrand, who became Pope Gregory VII (r. 1073–85), is associated with a radical and swift change in the Roman Church. The vision of a Christendom jointly administered by emperor and clergy, the famous model advanced by Pope Gelasius II (r. 492–96), was transformed into a new order where regnum and sacerdotium occupied separate stacked spheres, with the spiritual claiming superiority. Unlike tenth-century reform movements, the later eleventh-century Roman reforms centered on the papacy. Popes assembled a curia featuring more professional officials, legates, councils, and other technologies of power. The reformed Church cultivated trained lawyers and sympathetic lay leaders. It has been credited with launching a legal “big bang,” the invention of propaganda, the creation of a semi-institutionalized public sphere, and the formation of a persecuting society. Closer examination of institutional changes helps reveal the achievements and limits of this “new world order.”

The relationship of Catholic hierarchies with the medium of printing has always been multifarious, and even in early modern times it was far more complex than most current studies maintain. This chapter attempts to draw a concise and unbiased picture of the papacy’s publishing and censoring practices from the 1460s to the 1630s. It starts with the arrival of the first printers in Italy on the outskirts of Rome and ends with the Galileo Galilei affair, analyzing all intervening attempts to use moveable type in support of papal policy and the development of the Index of Forbidden Books. Highlighting the interconnections between prohibition and promotion, it proposes a unified interpretation of these two lines of action rather than present them in opposition, as is often the case.

The Christian community of Rome, since its origins, was adamant in preserving written texts. Documents and books of multiple kinds were treated as important, precious objects. The history of the popes’ libraries exemplifies this approach. In addition to spreading Christianity and keeping records of discussions and decisions taken by the Church, the library was intended as a repository not only of religious books but also of literary and scientific texts of non-Christian traditions, including pagan classics and others. The mission of ensuring the conservation and spreading of the knowledge was clearly stated during humanism, when the current Vatican Apostolic Library was founded. Books were there made accessible “for the common benefit of the learned.” Such a mission continues today. The papacy considers the Library and its books to be the “heritage of mankind,” one that needs to be made available for generations through continuous technological innovations and cutting-edge preservation strategies.