This article discusses the prospects and pitfalls of science-engaged theology (SET) – a new and growing movement in the science and religion discourse. The guiding question of this enquiry is why, when, and how theology should engage with the sciences. After introducing what I call the ‘source account’ of SET that has emerged in recent discussion, I show that this basic account often comes with additional commitments: the ‘no methodology’ and ‘locality and specificity’ theses, both of which address the ‘how’ question, and the ‘entanglement’ thesis, which addresses the ‘when’ question. I argue that accepting any of them as an essential feature makes SET methodologically flawed. To provide alternative answers, I then propose to interpret the sources of theology in terms of the so-called loci theologici. Recognizing the sciences specifically among the loci theologici alieni also helps to counter the view that SET may spell the end of the discipline of science and religion. The aim is, therefore, to show that the source account of SET, if taken in a minimal sense, is a valuable contribution to the science and religion discourse, without replacing it, whereas SET, if coupled with these additional assumptions, would and has considerably muddied the waters.