Yellow nutsedge (Cyperus esculentus L.) is one of the most problematic weeds in turfgrass due to its fast growth rate and high tuber production. Effective long-term control relies on translocation of systemic herbicides to underground tubers. Two identical trials were conducted simultaneously in separate greenhouses to evaluate the effect of several acetolactate synthase (ALS) and protoporphyrinogen oxidase (PPO) inhibiting postemergence herbicides on C. esculentus tuber production and viability. Seven tubers were planted into 1 L pots, and plants were allowed to mature for 6 weeks before trial initiation. Treatments included pyrimisulfan at 73 g ai ha-1 once or 49 g ai ha-1 twice, imazosulfuron at 736 g ai ha-1 once or 420 g ai ha-1 twice, carfentrazone-ethyl + sulfentrazone at 22 + 198 g ai ha-1 once or 14 + 127 g ai ha-1 twice, halosulfuron at 70 g ai ha-1 once or 35 g ai ha-1 twice, and a non-treated control. Sequential applications were made 3 weeks after initial treatment (WAIT) for both trials. Both single and sequential applications of carfentrazone-ethyl + sulfentrazone exhibited the quickest control (80 to 83% 4 WAIT). Two applications of imazosulfuron resulted in the greatest reduction in tuber number (81%) and tuber dry biomass (85%), while one application of carfentrazone-ethyl + sulfentrazone resulted in the greatest reduction in shoot biomass (71%). The viability of tubers that were recovered from each pot was reduced 48 to 70%, with the greatest reduction in response to carfentrazone-ethyl + sulfentrazone. Although two applications of pyrimisulfan only resulted in tuber number and shoot biomass reductions of 66% and 38%, respectively, tuber dry biomass reduction was 80%. Therefore, pyrimisulfan, imazosulfuron, halosulfuron, and carfentrazone-ethyl + sulfentrazone are all viable options for long-term C. esculentus control in turfgrass.