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Accepted manuscript

Triceps skinfold thickness is associated with all-cause mortality independent of BMI among maintenance hemodialysis patients

Published online by Cambridge University Press:  11 April 2025

Yaya Yang ,
Yan Huang ,
Qiuxia Zhong ,
Chaoying Xia ,
Jieyu Wang ,
Xiaolei Lan ,
Yaozhong Kong ,
Qijun Wan ,
Yumin Li  and
Sheng Huang
...Show all authors
Yaya Yang
Affiliation:
National Clinical Research Center for Kidney Disease, Nanfang Hospital; Guangdong Provincial Clinical Research Center for Kidney Disease; National Key Laboratory for Prevention and Treatment of Multi-organ Injury; Nephrology Department, Nanfang Hospital, Southern Medical University, Guangzhou, China,
Yan Huang
Affiliation:
National Clinical Research Center for Kidney Disease, Nanfang Hospital; Guangdong Provincial Clinical Research Center for Kidney Disease; National Key Laboratory for Prevention and Treatment of Multi-organ Injury; Nephrology Department, Nanfang Hospital, Southern Medical University, Guangzhou, China,
Qiuxia Zhong
Affiliation:
National Clinical Research Center for Kidney Disease, Nanfang Hospital; Guangdong Provincial Clinical Research Center for Kidney Disease; National Key Laboratory for Prevention and Treatment of Multi-organ Injury; Nephrology Department, Nanfang Hospital, Southern Medical University, Guangzhou, China,
Chaoying Xia
Affiliation:
National Clinical Research Center for Kidney Disease, Nanfang Hospital; Guangdong Provincial Clinical Research Center for Kidney Disease; National Key Laboratory for Prevention and Treatment of Multi-organ Injury; Nephrology Department, Nanfang Hospital, Southern Medical University, Guangzhou, China,
Jieyu Wang
Affiliation:
National Clinical Research Center for Kidney Disease, Nanfang Hospital; Guangdong Provincial Clinical Research Center for Kidney Disease; National Key Laboratory for Prevention and Treatment of Multi-organ Injury; Nephrology Department, Nanfang Hospital, Southern Medical University, Guangzhou, China,
Xiaolei Lan
Affiliation:
National Clinical Research Center for Kidney Disease, Nanfang Hospital; Guangdong Provincial Clinical Research Center for Kidney Disease; National Key Laboratory for Prevention and Treatment of Multi-organ Injury; Nephrology Department, Nanfang Hospital, Southern Medical University, Guangzhou, China,
Yaozhong Kong
Affiliation:
Nephrology Department, the First People’s Hospital of Foshan, Foshan, China,
Qijun Wan
Affiliation:
Nephrology Department, Shenzhen Second People’s Hospital, Shenzhen, China,
Yumin Li
Affiliation:
Nephrology Department, Huadu District People’s Hospital of Guangzhou, Guangzhou, China,
Sheng Huang
Affiliation:
Nephrology Department, Southern Medical University Affiliated Nanhai Hospital, Foshan, China,
Yan Liu
Affiliation:
Nephrology Department, Guangzhou Red Cross Hospital, Medical College of Jinan University, Guangzhou, China,
Aiqun Liu
Affiliation:
Nephrology Department, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China,
Fanna Liu
Affiliation:
Nephrology Department, Jinan University First Affiliated Hospital, Guangzhou, China.
Xianhui Qin
Affiliation:
National Clinical Research Center for Kidney Disease, Nanfang Hospital; Guangdong Provincial Clinical Research Center for Kidney Disease; National Key Laboratory for Prevention and Treatment of Multi-organ Injury; Nephrology Department, Nanfang Hospital, Southern Medical University, Guangzhou, China,
Youbao Li
Affiliation:
National Clinical Research Center for Kidney Disease, Nanfang Hospital; Guangdong Provincial Clinical Research Center for Kidney Disease; National Key Laboratory for Prevention and Treatment of Multi-organ Injury; Nephrology Department, Nanfang Hospital, Southern Medical University, Guangzhou, China,
Min Liang*
Affiliation:
National Clinical Research Center for Kidney Disease, Nanfang Hospital; Guangdong Provincial Clinical Research Center for Kidney Disease; National Key Laboratory for Prevention and Treatment of Multi-organ Injury; Nephrology Department, Nanfang Hospital, Southern Medical University, Guangzhou, China,
*
*Correspondence: Min Liang; Email: [email protected]
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Abstract

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Triceps skinfold thickness (TSF) is a surrogate marker of subcutaneous fat. Evidence is limited about the association of sex-specific TSF with the risk of all-cause mortality among maintenance hemodialysis (MHD) patients. We aimed to investigate the longitudinal relationship of TSF with all-cause mortality among MHD patients. A multicenter prospective cohort study was performed in 1034 patients undergoing MHD. The primary outcome was all-cause mortality. Multivariable Cox proportional hazards models were used to evaluate the association of TSF with the risk of mortality. The mean (standard deviation) age of the study population was 54.1 (15.1) years. 599 (57.9%) of the participants were male. The median (interquartile range) of TSF was 9.7 (6.3–13.3 mm) in males and 12.7 (10.0–18.0 mm) in females. Over a median follow up of 4.4 years (interquartile range, 2.4-7.9 years), there were 548 (53.0%) deaths. When TSF was assessed as sex-specific quartiles, compared with those in quartile 1, the adjusted HRs (95%CIs) of all-cause mortality in quartile 2, quartile 3 and quartile 4 were 0.93 (0.73, 1.19), 0.75 (0.58, 0.97) and 0.69 (0.52, 0.92), respectively (P for trend =0.005). Moreover, when analyzed by sex, increased TSF (≥9.7 mm for males and ≥18mm for females) was significantly associated with a reduced risk of all-cause mortality (quartile 3-4 vs. quartile 1-2; HR, 0.70; 95%CI: 0.55, 0.90 in males; quartile 4 vs. Quartile 1-3; HR, 0.69; 95%CI: 0.48, 1.00 in females). In conclusion, high TSF was significantly associated with lower risk of all-cause mortality in MHD patients.

Keywords

fat distributionsubcutaneous fattriceps skinfold thicknessmortalitymaintenance hemodialysis
Type
Research Article
Information
British Journal of Nutrition , Accepted manuscript , pp. 1 - 19
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of The Nutrition Society

Footnotes

†

These authors have contributed equally to this work