Published online by Cambridge University Press: 21 November 2024
Tardive dyskinesia (TD) is a movement disorder characterized by intermittent or continuous hyperkinetic involuntary movements caused by the use of neuroleptic medications, specifically dopamine receptor antagonists, a common mechanism of antipsychotic medications. Though most commonly seen in patients taking dopamine receptor blocking medications, TD can also be seen in patients taking antihistamine and serotonergic medications. These abnormal movements are often most prominent in the orofacial and lingual muscles (lip-smacking, tongue protrusion), though can be seen in the upper- and lower-extremities, nuchal, and truncal muscles. The specific involuntary movements experienced in TD can vary widely between patients, and can include choreiform, dystonic, and stereotyped movements, as well as motor and/or vocal tics and akathisia, particularly in the legs.
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