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Chapter 3 - Pathophysiology of Chronic Endometritis

Published online by Cambridge University Press:  16 April 2025

By
Jacqueline Chung Pui Wah ,
Judy Zhang Tao  and
Tin Chiu Li
Edited by
Roy G. Farquharson ,
Mary D. Stephenson  and
Mariëtte Goddijn
Roy G. Farquharson
Affiliation:
Liverpool Women’s Hospital
Mary D. Stephenson
Affiliation:
University of Illinois, Chicago
Mariëtte Goddijn
Affiliation:
Amsterdam University Medical Centers
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Summary

This book chapter provides an overview of chronic endometritis (CE), a condition which is increasingly recognized as being associated with recurrent implantation failure, recurrent miscarriage, and fetal demise. The diagnosis of CE is challenging due to the presence of various cell types in the endometrial stroma, making the identification of plasma cells essential. The optimal timing and diagnostic evaluation of endometrial biopsy are still being researched, while immunohistological staining may improve the identification of plasma cells. Hysteroscopy and endometrial culture may also aid in diagnosis and guide antibiotic selection. Although antibiotic treatment has shown improved pregnancy outcomes in cases of CE, there is no established ideal regimen. Overall, this chapter provides valuable information on CE and highlights the need for continued research to improve diagnosis and treatment.

Keywords

Chronic endometriosisrecurrent implantation failure, recurrent miscarriageplasma cellsdiagnosisantibiotic treatmenttest of cure
Type
Chapter
Information
Early Pregnancy , pp. 13 - 21
Publisher: Cambridge University Press
Print publication year: 2025

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References

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