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Chapter 27 - Dynamic Prediction Models for Recurrent Pregnancy Loss

Published online by Cambridge University Press:  16 April 2025

By
Marie-Louise van der Hoorn ,
Mariëtte Goddijn  and
Eileen Lashley
Edited by
Roy G. Farquharson ,
Mary D. Stephenson  and
Mariëtte Goddijn
Roy G. Farquharson
Affiliation:
Liverpool Women’s Hospital
Mary D. Stephenson
Affiliation:
University of Illinois, Chicago
Mariëtte Goddijn
Affiliation:
Amsterdam University Medical Centers
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Summary

In the absence of evidence-based therapeutic options for the majority of couples with recurrent pregnancy loss (RPL) it is considered significant to offer supportive care, including reliable counseling regarding the prognosis of subsequent pregnancies. Currently, various prediction models are available, with a focus on couples with unexplained RPL. All of them having drawbacks like substantial risk of bias, lack of performance measures and applicability. A new prediction model, using more predictors, such as male predictors and focusing on cumulative live birth rates over a reasonable time period is currently needed. In addition, this model should have the ability to provide reliable predictions at later time points, a so-called dynamic prediction model.

Keywords

Recurrent pregnancy lossPrediction modelSupportive carePregnancy
Type
Chapter
Information
Early Pregnancy , pp. 292 - 298
Publisher: Cambridge University Press
Print publication year: 2025

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References

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