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Chapter 4 - Clinical Management of Chronic Endometritis in Recurrent Pregnancy Loss

Published online by Cambridge University Press:  16 April 2025

By
Elena HogenEsch  and
Lia A. Bernardi
Edited by
Roy G. Farquharson ,
Mary D. Stephenson  and
Mariëtte Goddijn
Roy G. Farquharson
Affiliation:
Liverpool Women’s Hospital
Mary D. Stephenson
Affiliation:
University of Illinois, Chicago
Mariëtte Goddijn
Affiliation:
Amsterdam University Medical Centers
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Summary

Chronic endometritis (CE) is an inflammatory condition of the endometrium that may be caused by bacterial infection and has been associated with poor reproductive outcomes in patients with recurrent pregnancy loss (RPL), recurrent implantation failure after embryo transfer (RIF), and infertility of unexplained etiology. Different criteria are used amongst clinicians to diagnose CE and this lack of consensus surrounding the diagnosis of CE has led to challenges estimating the true prevalence of CE. Similarly, the absence of a gold standard for diagnosing CE has limited efforts to study treatment efficacy, although most experts support treating CE with oral antibiotics. In this chapter we review how CE is diagnosed, evaluate etiologies of CE and discuss treatments and outcomes after treatment.

Keywords

Chronic endometritisrecurrent pregnancy lossrecurrent implantation failureuterine microbiome
Type
Chapter
Information
Early Pregnancy , pp. 22 - 31
Publisher: Cambridge University Press
Print publication year: 2025

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References

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