Christianity in the Midwestern United States captures the range of Christianity across the country: Catholic, Protestant and Orthodox. Twelve states form the Midwest: Ohio, Michigan, Indiana, Illinois, Wisconsin, Minnesota, North Dakota, South Dakota, Missouri, Kansas, Iowa and Nebraska. These states represent Middle America, standing between the two coasts, East and West, and the South.

By the early 2000s, the Midwest had become a major centre of Evangelicalism, an expression of conservative Protestantism. Collectively, the Midwest's Pentecostal and Holiness denominations along with non-denominational congregations constitute 26.1% of the Protestant population in the region. When one includes conservatives of Lutheran, Presbyterian, Reformed, Congregationalist, Baptist and other persuasions, the conservative Protestant population is even higher. With headquarters, publishing houses, schools, colleges and mega-churches in the region, they exercise a major presence.

After the Evangelicals, the Midwest is Baptist in a way that escapes the South's Baptist conservatism. Its breed is mainline Baptist in contrast to the popular style of the Southern Baptists. As mainline Protestants, the American Baptists reinforce the influence of mainline Protestantism in this part of the country. The Baptists are the region's second-largest community of Protestants. Of the Protestants in the Midwest, Baptists (23.1%) are followed by Lutherans (16.9%) and Methodists (12%). Whereas the Baptists (43.6%) in the South are mostly members of the Southern Baptist Convention, who along with other Evangelical Protestants reinforce the conservative tenor and church-going culture of the South, the mainline Baptists in the Midwest have more in common with other mainline churches such as Lutheran, Methodist and Presbyterian.

Lutheranism too makes its mark on the Midwest. The region was Lutheran country during much of the twentieth century. Demographically, the Upper Midwest still holds that distinction. The Upper Midwest states of North Dakota and Minnesota anchor Lutheranism for the region. In North Dakota, for instance, 56% of Protestants are Lutheran, and in Minnesota 49% are. The Midwest overall is the Lutheran epicentre of the USA. Lutherans, who are a defining religious factor in the Midwest, sponsor at least 20 denominations with headquarters in the region; these include the two largest Lutheran communions in the nation. Lutherans shape this region more than any other. American Lutheranism shapes the character of this part of the world.