This chapter surveys the interrelated histories of literature, religion, and politics in the nineteenth-century United States. In the wake of official church disestablishment, a wave of religious fervor combined with a rising tide of immigrants to form a nation in which literature became a venue for conversion, condemnation, and cultural affirmation. From early national historical romances that sought to confirm the new nation as God’s (Protestant) chosen land to Transcendentalist writings that celebrated the sacredness of the individual American soul, nineteenth-century literature tied American identity to religious pluralism and personal devotion. Sentimental novels penned by women writers and narratives of escape written by the formerly enslaved fitted religious tropes of conversion and resurrection to visions of social reform and political regeneration, while Mormons, Millerites, Shakers, Spiritualists, and other religious innovators developed new models of spiritual identity and literary language suited to an expansive and imperial nation. Over the course of the century, literature served as a venue for theological debate, a vehicle for conversion, a passionate plea for abused humanity, and an imaginative space for envisioning social reform. In each of these modes, authors of literature intervened not only in religious discourses but in the vital political life of the nation.