Guinea pigs (Cavia porcellus) have been consumed and revered in South American countries since precolonial times and continue to serve as both an important protein source and an economic driver for underserved and remote communities in the region. However, currently, there is limited peer-reviewed research on the welfare status of these animals in meat production systems. This scoping review seeks to provide an overview of guinea pig meat production in the region, highlighting potential welfare challenges and exploring opportunities to advance animal welfare practices within these systems.