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In June 2020, the German Federal Government adopted its National Hydrogen Strategy (NWS), which was updated in July 2023, viewing green hydrogen as a key to the energy transition. To achieve net greenhouse gas neutrality by 2045, as required by law, the NWS envisages a rapid market ramp-up for hydrogen. This policy is supported by the recent amendment of the Energy Industry Act (EnWG), which introduces provisions for a prompt creation of a so-called hydrogen core network. However, for now, the required infrastructure does not exist. Against that background, this chapter will examine the existing permission regime in Germany for pure hydrogen infrastructure, specifically its transportation via pipelines and its large-scale storage in salt caverns as the best short-term storage option. The analytical focus will be trained on existing legal barriers that stand in the way of accelerating the construction and repurposing of infrastructure to disseminate hydrogen. To secure the planning and approval framework for the rapid expansion of hydrogen infrastructures in Germany, necessary adjustments to the current legal framework are proposed.
Chapter 1 begins by considering three instances of Faulkner’s writing reused in new contexts: Malcolm Cowley’s 1946 Portable Faulkner; a commonplace book of Faulkner quotations published in 2000; and the current use of the line from his 1951 book Requiem for a Nun, “The past is never dead. It’s not even past,” as a widely circulated shorthand for persistent racial inequities that makes him, for many readers, more relevant today than at the height of his post-Nobel fame in the 1950s. While Faulkner seems to have meant this line as a critique of one character’s view, he likely would not object to the current use of the phrase due to his particular view of history whereby old artistic works take on new life by their use in the present. The chapter examines how Faulkner’s 1936 novel Absalom, Absalom! stages the issue of using documents, here in the form of letters, to construct an historical narrative. While Faulkner is widely understood today as a kind of historian, this chapter shows how he is more concerned with the ways in which historical texts, along with works of the imagination, create a sense of the past as an inherently multimedia endeavor.
Drug repositioning refers to the development of a drug for an indication other that in the marketing authorisation and drug repurposing is the use of known drugs for new indications. Both repositioning and repurposing are opportunities to complement traditional drug development and may shorten the time for a drug to reach the patient. This chapter provides a detailed overview of the pharmacological, preclinical, clinical and epidemiological evidence for four drugs or drug classes currently considered as the highest priority candidates for repurposing in Alzheimer’s disease: fasudil, phenserine, antiviral drugs and glucagon-like peptide 1 (GLP-1) analogs. In addition, key considerations on the future of repurposing are provided, including the role of transcriptional approaches and targeting risk genes and growth factors.
In the article Analysis of the impact of antidepressants and other medications on COVID-19 infection risk in a chronic psychiatric in-patient cohort, Catherine L. Clelland and colleagues for the first time suggest a protective effect of antidepressants against infection with coronavirus disease 2019 (COVID-19) itself. During the observation period of the first wave of the pandemic in New York, more than 50% of patients in the psychiatric hospital studied were infected. From retrospective analysis of the hospital medical records, the authors found a significantly lower risk for infection in patients with antidepressant medication compared to treatment with other psychiatric drugs. The findings of a reduced infection incidence in patients who were already on antidepressant drug therapy underlines a preventive efficacy of antidepressants against COVID-19. Taken together with the prior obtained data of efficacy against deterioration of COVID-19 disease, this study adds a piece of evidence to the positive benefit-risk of antidepressants in repurposing condition against COVID-19.
Leishmaniasis is a vector-borne neglected tropical disease caused by protozoan parasites of the genus Leishmania for which there is a paucity of effective viable non-toxic drugs. There are 1·3 million new cases each year causing considerable socio-economic hardship, best measured in 2·4 million disability adjusted life years, with greatest impact on the poorest communities, which means that desperately needed new antileishmanial treatments have to be both affordable and accessible. Established medicines with cheaper and faster development times may hold the cure for this neglected tropical disease. This concept of using old drugs for new diseases may not be novel but, with the ambitious target of controlling or eradicating tropical diseases by 2020, this strategy is still an important one. In this review, we will explore the current state-of-the-art of drug repurposing strategies in the search for new treatments for leishmaniasis.
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