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Hypertension disorders of pregnancy are a clinical spectrum that includes gestational hypertension, preeclampsia, and eclampsia. Hypertensive disorders are a common cause of significant maternal and fetal morbidity and mortality. Therefore, it is important for women’s health clinicians to be knowledgeable of the diagnostic criteria and management guidelines. A 25-year-old gravida 3 para 0 at 35 weeks’ gestation presents with a blood pressure of 165/95, proteinuria, and develops seizures. Based on her clinical presentation, physical examination, and laboratory findings, a diagnosis of eclampsia was made. The patient was promptly stabilized, treated with magnesium sulfate for seizure prophylaxis, received antihypertensive treatment, and delivered in a timely manner. The case highlights the recommended maternal evaluation, fetal surveillance, timing of delivery, and treatment for hypertension disorders of pregnancy.
Preterm labor, marked by cervical changes between 20 0/7 and 36 6/7 weeks’ gestation, is a significant contributor to preterm birth, accounting for 50% of such cases and is associated with increased neonatal mortality and long-term health issues. Understanding preterm labor involves considering diverse factors, including maternal medical history, demographics, and current pregnancy characteristics. Modifiable risk factors such as short interpregnancy intervals and substance use play a role in its onset. Diagnostic tools like transvaginal ultrasonography and fetal fibronectin aid in identifying at-risk individuals. Effective management of preterm labor is a pivotal aspect of obstetric care. Tocolytics, antenatal corticosteroids, and group B streptococcus prophylaxis are integral interventions. Decisions about the mode of delivery include the potential benefits of cesarean delivery in extreme prematurity. This case underscores the importance of vigilant monitoring, timely diagnosis, and intervention in addressing preterm labor, thereby mitigating its adverse effects on maternal and neonatal health.
The spectrum of neurologic emergencies in pregnancy extends from life-threatening eclamptic seizures to self-limiting paresthesias. Pregnancy markedly modifies human physiology, creating a unique and challenging physical and laboratory evaluation. In addition, pregnant patients may present with gestational and peripartum conditions resulting directly from pregnancy, but also a portent of future disease as well as exacerbation of pre-existing conditions changed by the patient’s gravid state. All of these issues can be complicated by the “second patient” (the fetus), which requires careful consideration.
Eclampsia is associated with increased risk of maternal and fetal morbidity and mortality. Aggressive attempts should be made to control seizures and hypertension. It usually develops after 20 weeks of gestation and just over one-third of cases occur at term, usually developing intrapartum or within 48 hours of delivery. Two hypotheses have been proposed: (1) cerebral overregulation in response to high blood pressure results in vasospasm of cerebral arteries, localized ischemia, and intracellular edema; (2) loss of autoregulation of cerebral blood flow in response to high blood pressure results in hyperperfusion, and vasogenic edema. In addition to the management principles that apply to other seizures with different etiologies such as prevention of hypoxia, trauma, and recurrent seizures, management of eclamptic seizures includes control of severe hypertension if present, and evaluation for prompt delivery. Magnesium sulfate is considered the drug of choice for prevention and treatment of eclampsia.
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