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Reviewer Comment on Taghdiri et al. “Access to Endovascular Thrombectomy: Does Driving Time to Comprehensive Stroke Center Matter More than Rurality?”

Published online by Cambridge University Press:  17 March 2025

Mahesh Kate*
Affiliation:
Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Aleksander Tkach
Affiliation:
Kelowna General Hospital, Kelowna, British Columbia, Canada
*
Corresponding author: Mahesh Kate; Email: [email protected]
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Abstract

Type
Reviewer Comment
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of Canadian Neurological Sciences Federation

Endovascular thrombectomy (EVT) in eligible acute ischemic stroke (AIS) treatment is associated with an increased likelihood of excellent functional outcomes in a cost-effective manner. However, EVT is resource-intensive and available only at comprehensive stroke centers or EVT-capable centers. Access to EVT is deficient in high-income countries Reference Kamel, Parikh and Chatterjee1,Reference Eagles, Beall, Ben-Israel, Wong, Hill and Spackman2 and worse in low- and middle-income countries. Reference Asif, Otite and Desai3 One of the key barriers to EVT access is geographical: driving time is defined as the distance between the patient’s residence and the nearest EVT-capable site.

Taghdiri F et al. Reference Taghdiri, Vyas and Kapral4 conducted an interesting retrospective population-based cohort study to explore driving time as a metric to understand EVT access. Over 5 years, they included n = 57,587 adult patients hospitalized with a diagnosis of acute ischemic stroke, 4150 received EVT and 8285 received intravenous thrombolysis (IVT). Driving time to an EVT-capable site was calculated as travel time by a car while accounting for speed limits in Ontario and divided into three groups: <20 (n = 25,180), 20 – 60 (n = 20,029) and >60 (12,478) minutes. The authors observed that the likelihood of receiving EVT was reduced beyond 120 minutes of driving time to the nearest EVT-capable site. This is an important insight into geographic disparities in stroke care access.

Driving time indicates remoteness but may be associated with other socioeconomic disparities. In a study from Alberta, patients living in the most deprived neighborhoods were 50% less likely to receive EVT; these areas had a median driving distance of >74 Km. Reference Eagles, Beall, Ben-Israel, Wong, Hill and Spackman2 A study from Wisconsin noted that long drive distances from advanced-care-capable stroke centers were associated with increased mortality. Reference Halada, Beyer, Zhou and Weston5 These are important factors as many Canadians live more than 120 minutes from an EVT center.

Therefore, traditional strategies of urban areas, such as the drip-and-ship versus bypass model, may not work in remote areas as the driving time increases. Reference Yu, Panagos and Kansagra6 Yet, important system-level improvements are still needed: shortening door-to-neurology contact, decreasing door-in door-out times and improving air transportation may be helpful. Novel solutions are also needed, such as neuro-cytoprotection and detection of large vessel occlusion by non-computed tomography-based tools for better bypass strategies. Mobile stroke units may improve access in some jurisdictions. Reference Kate, Jeerakathil and Buck7,Reference Mac Grory, Sun and Alhanti8

Reliance on driving time as a metric has some limitations. It is a nonphysiological variable that may be influenced by jurisdictional speed limit laws and real-time challenges (weather and driving conditions). Driving time may also vary based on advanced cardiac life support, ambulance and air transport. Nevertheless, driving time is a viable model for identifying EVT access deserts worldwide.

Competing interests

MK holds grants from Health Everywhere Hub, the Canadian Institute of Health Research, the University Hospital Foundation, the Translational Research Fund, and Department of Medicine Startup Funds, the University of Alberta. AT is the Financial Chair and Executive Board Member of the Canadian Stroke Consortium and Medical Director for the Interior Health Stroke Network.

References

Kamel, H, Parikh, NS, Chatterjee, A et al. Access to mechanical thrombectomy for ischemic stroke in the United States. Stroke. 2021;52:25542561. DOI: 10.1161/STROKEAHA.120.033485.CrossRefGoogle ScholarPubMed
Eagles, ME, Beall, RF, Ben-Israel, D, Wong, JH, Hill, MD, Spackman, E. Neighbourhood deprivation, distance to nearest comprehensive stroke centre and access to endovascular thrombectomy for ischemic stroke: a population-based study. CMAJ Open. 2023;11:E1181E1187. DOI: 10.9778/CMAJO.20230046.CrossRefGoogle ScholarPubMed
Asif, KS, Otite, FO, Desai, SM et al. Mechanical thrombectomy global access for stroke (MT-GLASS): a mission thrombectomy (MT-2020 plus) study. Circulation. 2023;147:12081220. DOI: 10.1161/CIRCULATIONAHA.122.063366.CrossRefGoogle ScholarPubMed
Taghdiri, F, Vyas, MV, Kapral, MK et al. Access to endovascular thrombectomy: does driving time to comprehensive stroke center matter more than rurality?. Can J Neurol Sci. 2025. DOI: 10.1017/cjn.2025.15.CrossRefGoogle ScholarPubMed
Halada, S, Beyer, KM, Zhou, Y, Weston, BW. Navigating stroke care: geospatial assessment of regional stroke center accessibility. J Stroke Cerebrovasc Dis. 2024;33:108093. DOI: 10.1016/J.JSTROKECEREBROVASDIS.2024.108093.CrossRefGoogle ScholarPubMed
Yu, CY, Panagos, PD, Kansagra, AP. Travel time and distance for bypass and non-bypass routing of stroke patients in the United States. J Neurointerv Surg. 2022;15:634638. DOI: 10.1136/NEURINTSURG-2022-018787.CrossRefGoogle Scholar
Kate, MP, Jeerakathil, T, Buck, BH. Pre-hospital triage of suspected acute stroke patients in a mobile stroke unit in the rural Alberta. Sci Rep. 2021;11:4988. DOI: 10.1038/s41598-021-84441-0 CrossRefGoogle Scholar
Mac Grory, B, Sun, JL, Alhanti, B et al. Mobile stroke unit management in patients with acute ischemic stroke eligible for intravenous thrombolysis. JAMA Neurol. 2024;81:1250. DOI: 10.1001/JAMANEUROL.2024.3659.CrossRefGoogle ScholarPubMed