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From resting potential to dynamics: advances in membrane voltage indicators and imaging techniques

Published online by Cambridge University Press:  16 January 2025

Reyhaneh Shakibi Open the ORCID record for Reyhaneh Shakibi [Opens in a new window] ,
Fatemeh Yazdipour Open the ORCID record for Fatemeh Yazdipour [Opens in a new window] ,
Hamed Abadijoo Open the ORCID record for Hamed Abadijoo [Opens in a new window] ,
Navid Manoochehri Open the ORCID record for Navid Manoochehri [Opens in a new window] ,
Farshid Rostami Pouria Open the ORCID record for Farshid Rostami Pouria [Opens in a new window] ,
Taraneh Bajooli Open the ORCID record for Taraneh Bajooli [Opens in a new window] ,
Hossein Simaee Open the ORCID record for Hossein Simaee [Opens in a new window] ,
Parviz Abdolmaleki Open the ORCID record for Parviz Abdolmaleki [Opens in a new window] ,
Ali Khatibi Open the ORCID record for Ali Khatibi [Opens in a new window]  and
Mohammad Abdolahad Open the ORCID record for Mohammad Abdolahad [Opens in a new window]
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Reyhaneh Shakibi
Affiliation:
Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran Integrated Biophysics and Bioengineering Lab (iBL), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
Fatemeh Yazdipour
Affiliation:
Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran Integrated Biophysics and Bioengineering Lab (iBL), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
Hamed Abadijoo
Affiliation:
Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran Integrated Biophysics and Bioengineering Lab (iBL), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran
Navid Manoochehri
Affiliation:
Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran Integrated Biophysics and Bioengineering Lab (iBL), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran
Farshid Rostami Pouria
Affiliation:
Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran Integrated Biophysics and Bioengineering Lab (iBL), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran
Taraneh Bajooli
Affiliation:
Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran Integrated Biophysics and Bioengineering Lab (iBL), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, Tehran, Iran
Hossein Simaee
Affiliation:
Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran Integrated Biophysics and Bioengineering Lab (iBL), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
Parviz Abdolmaleki
Affiliation:
Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
Ali Khatibi
Affiliation:
Department of Biotechnology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran
Mohammad Abdolahad
Affiliation:
Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran
Ali Akbar Moosavi-Movahhedi
Affiliation:
Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran
Mohammad Ali Khayamian*
Affiliation:
Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran Integrated Biophysics and Bioengineering Lab (iBL), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
*
Corresponding author: Mohammad Ali Khayamian; Emails: [email protected]; [email protected]
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Abstract

The membrane potential is a critical aspect of cellular physiology, essential for maintaining homeostasis, facilitating signal transduction, and driving various cellular processes. While the resting membrane potential (RMP) represents a key physiological parameter, membrane potential fluctuations, such as depolarization and hyperpolarization, are equally vital in understanding dynamic cellular behavior. Traditional techniques, such as microelectrodes and patch-clamp methods, offer valuable insights but are invasive and less suited for high-throughput applications. Recent advances in voltage indicators, including fast and slow dyes, and novel imaging modalities such as second harmonic generation (SHG) and photoacoustic imaging, enable noninvasive, high-resolution measurement of both RMP and membrane potential dynamics. This review explores the mechanisms, development, and applications of these tools, emphasizing their transformative potential in neuroscience and cellular electrophysiology research.

Keywords

BODIPYsphotoacoustic imagingquantum dotresting membrane potential (RMP)second harmonic generationgenetically encoded voltage indicators
Type
Review
Information
Quarterly Reviews of Biophysics , Volume 58 , 2025 , e7
Copyright
© The Author(s), 2025. Published by Cambridge University Press

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This article was originally published with incomplete funding information. The error has been corrected and the online HTML and PDF versions updated.

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