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A Single-Patient, Self-Controlled and Self-Recorded Trial of Wy 3498

Published online by Cambridge University Press:  29 January 2018

Frank M. McPherson  and
John Le. Gassicke
Frank M. McPherson
Affiliation:
Department of Psychological Medicine, University of Edinburgh, Professorial Unit, Jordanburn Nerve Hospital, Edinburgh, 10
John Le. Gassicke
Affiliation:
Department of Psychological Medicine, University of Edinburgh, Professorial Unit, Jordanburn Nerve Hospital, Edinburgh, 10
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Extract

This paper describes the preliminary clinical testing of a new sedative drug, and also explores the feasibility of using a single-patient, self-controlled and recorded design in psychiatric drug trials. Hogben and Sim (1953) demonstrated a form of drug trial which emphasized intra-subject fluctuations and their control. Recently, Shapiro (1963) has argued the usefulness of a similar approach in fundamental, clinical research. However, the single-patient drug trial appears not to have been widely used in psychiatry, although several writers, e.g. Shepherd (1963), have indicated its possible advantages.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 111 , Issue 471 , February 1965 , pp. 149 - 154
Copyright
Copyright © Royal College of Psychiatrists, 1965 

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References

Cox, D. R. (1961). “Design of experiments, the control of error.” J. Roy. Statist. Soc. Ser. A, 124, 44–48.CrossRefGoogle Scholar
Foulds, G. A. (1963). “The objectivity of personal relationships and the subjectivity of science.” Paper delivered at Conference of the Society for Psychosomatic Research.Google Scholar
Hogben, L., and Sim, M. (1953). “The self-controlled and self-recorded clinical trial for low-grade morbidity.” Brit. J. prev. soc. Med., 7, 163–179.Google Scholar
Le Gassicke, J. and McPherson, F. M. (1965). “A sequential trial of Wy 3498.” In preparation.Google Scholar
Maxwell, A. E. (1958). Experimental Design in Psychology and the Medical Sciences. Methuen & Co. Google Scholar
Phillips, J. P. N. (1961). Technical Aspects of the Questionnaire (unpublished).Google Scholar
Scott, W. A., and Wertheimer, M. (1962). Introduction to Psychological Research. New York: John Wiley & Sons Inc.Google Scholar
Shapiro, M. B. (1961). “A method of measuring psychological changes specific to the individual psychiatric patient.” Brit. J. med. Psychol., 34, 151–155.Google Scholar
Shapiro, M. B. (1963). “A clinical approach to fundamental research with special reference to the study of the single patient”, in Methods of Psychiatric Research (ed. Sainsbury, and Kreitman, ). London: Oxford University Press.Google Scholar
Shapiro, M. B., Marks, I. M., and Fox, B. (1963). “A therapeutic experiment on phobic and affective symptoms.” Brit. J. soc. clin. Psychol., 2, 81–93.CrossRefGoogle Scholar
Shepherd, M. (1963). “The evaluation of treatment in psychiatry”, in Methods of Psychiatric Research (ed. Sainsbury, and Kreitman, ). London: Oxford University Press.Google Scholar
Sidman, M. (1960). Tactics of Scientific Research. New York: Basic Books Inc.Google Scholar
Thorpe, J. G., and Baker, A. A. (1959). “Statistics, science and psychiatry.” A.M.A. Arch. gen. Psychiat., 1, 338–341.CrossRefGoogle Scholar
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