Hostname: page-component-55f67697df-q9hcs Total loading time: 0 Render date: 2025-05-11T04:26:05.011Z Has data issue: false hasContentIssue false
  • English
  • Français

The Leucocyte Antigenic System HL-A as a Possible Genetic Marker of Schizophrenia

Published online by Cambridge University Press:  29 January 2018

C. L. Cazzullo ,
E. Smeraldi  and
G. Penati
C. L. Cazzullo
Affiliation:
Institute of Clinical Psychiatry of the Milan Medical School, Via G. Besta 1, 20161 Milano/Affori, Italy
E. Smeraldi
Affiliation:
Institute of Clinical Psychiatry of the Milan Medical School, Via G. Besta 1, 20161 Milano/Affori, Italy
G. Penati
Affiliation:
Institute of Clinical Psychiatry of the Milan Medical School, Via G. Besta 1, 20161 Milano/Affori, Italy
Get access Rights & Permissions [Opens in a new window]

Extract

Many inheritance models of schizophrenia have been proposed, in view of its variable age at onset, variable familial occurrence and the relevant influence of a great number of environmental factors (Gottsman and Shields, 1967; Heston, 1970; Ödegård, 1972). However, the real genetic predisposition to schizophrenia has not yet been experimentally verified, and genetic markers have to be looked for, i.e. we need some character, genetically determined, whose transmission is associated with schizophrenia transmission: the more polymorphous the character, the greater will be the probability of finding such associations.

Type
Abstract
Information
The British Journal of Psychiatry , Volume 125 , Issue 584 , July 1974 , pp. 25 - 27
Copyright
Copyright © Royal College of Psychiatrists, 1974 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Gazzullo, C. L. & Smeraldi, E. (1972) HL-A antigens and multiple sclerosis. Lancet, ii, 429.Google Scholar
Gottsmann, I. I. & Shields, J. (1967) A polygenic theory of schizophrenia. Proceedings of National Academy of Sciences, 58, 199.CrossRefGoogle Scholar
Heston, L. L. (1970) The genetics of schizophrenic and schizoid disease. Science, 167, 249.Google Scholar
Kissmeyer-Nielsen, F. (1972) Serological identification of human transplantation antigens: The HL-A system, in Transplantation Antigens-Markers of Biological Individuality (ed. Kahan, & Reisfeld, ). New York and London.CrossRefGoogle Scholar
Kissmeyer-Nielsen, F. & Thorsby, E. (1970) Human transplantion antigens. Transplantation Reviews, 4, 1.Google Scholar
Mittal, K. K., Mickey, M. R. & Terasaki, P. I. (1968) Serotyping for homotransplantation. XVIII. Refinement of the microdroplet cytotoxicity test. Transplantation, 6, 913.CrossRefGoogle Scholar
Ödeoard, O. (1972) The multifactorial theory of inheritance in predisposition to schizophrenia, in Genetic Factors in Schizophrenia (ed. Kaplan, A. R.), p. 256. Thomas, Springfield, Ill.Google Scholar
Planansky, K. (1972) Phenotypic boundaries and genetic specificity in schizophrenia, in Genetic Factors in Schizophrenia (ed. Kaplan, A. R.), p. 141. Thomas, Springfield, Ill.Google Scholar
Russel, T. J., Schultes, L. M. & Kuban, D. J. (1972) Histocompatibility (HL-A) antigens associated with psoriasis. New England Journal of Medicine, 287, 738.CrossRefGoogle Scholar
Snezhnevsky, A. V. & Vartanyan, M. (1970) The forms of schizophrenia and their biological correlates, in Biochemistry, Schizophrenias and Affective Illnesses (ed. Himwich, H.), p. 1. Baltimore: Williams & Wilkins.Google Scholar
Walford, R. L., Smith, G. S. & Waters, H. (1971) Histocompatibility systems and disease states, with particular reference to cancer. Transplantation Reviews, 7, 78.Google ScholarPubMed
Submit a response

eLetters

No eLetters have been published for this article.