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Efficacy of bupropion for smoking cessation in smokers with a former history of major depression or alcoholism∗

Published online by Cambridge University Press:  02 January 2018

Kara E. Hayford ,
Christi A. Patten ,
Teresa A. Rummans ,
Darrell R. Schroeder ,
Kenneth P. Offord ,
Ivana T. Croghan ,
Elbert D. Glover ,
David P. L. Sachs  and
Richard D. Hurt
Kara E. Hayford
Affiliation:
Department of Psychiatry, Mayo Clinic, Rochester
Christi A. Patten*
Affiliation:
Department of Psychology, Mayo Clinic
Teresa A. Rummans
Affiliation:
Department of Psychiatry, Mayo Clinic
Darrell R. Schroeder
Affiliation:
Section of Biostatistics, Mayo Clinic
Kenneth P. Offord
Affiliation:
Section of Biostatistics, Mayo Clinic
Ivana T. Croghan
Affiliation:
Nicotine Dependence Center, Mayo Clinic
Elbert D. Glover
Affiliation:
Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506
David P. L. Sachs
Affiliation:
Palo Alto Center for Pulmonary Disease Prevention, Palo Alto, CA 94301
Richard D. Hurt
Affiliation:
Nicotine Dependence Center, Mayo Clinic
*
Christi A. Patten, Nicotine Research Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Fax: (507) 266-7900; e-mail: [email protected]
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Abstract

Background

A past history of major depression or alcoholism has been associated with poorer smoking treatment outcomes.

Aim

To evaluate the efficacy of bupropion for smoking cessation in smokers with a former history of major depression or alcoholism, and changes in depressive symptoms during smoking abstinence.

Method

Data were drawn from a multicentre trial of bupropion for smoking cessation. Smokers (n=615) received placebo or bupropion sustained-release at 100, 150, or 300 mg/day for six weeks after target quit date (TQD). The primary outcome was the point prevalence smoking abstinence at the end of treatment and at one year. The Beck Depression Inventory (BDI) was used to assess depressive symptoms.

Results

A significant dose – response effect of bupropion for smoking cessation was found. This was independent of history of major depression or alcoholism. Among those continuously abstinent from smoking for two weeks following TQD, an increase in BDI score was associated with a return to smoking at end of treatment.

Conclusions

Bupropion is efficacious for smoking cessation independently of a former history of major depression or alcoholism. Increases in depressive symptoms during an initial period of abstinence are associated with a return to smoking.

Type
Papers
Information
The British Journal of Psychiatry , Volume 174 , Issue 2 , February 1999 , pp. 173 - 178
Copyright
Copyright © 1999 The Royal College of Psychiatrists 

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Footnotes

∗.

Presented in part at the American Psychiatric Association annual meeting, San Diego. May, 1997 and the American Society of Addiction Medicine National Conference on Nicotine Dependence, Minneapolis, October, 1997.

Declaration of interest Supported by a grant from Glaxo Wellcome Inc.

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