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Ionic regulation of egg activation

Published online by Cambridge University Press:  17 March 2009

M. J. Whitaker  and
R. A. Steinhardt
M. J. Whitaker
Affiliation:
Department of Physiology, University College London, Gower Street, London WC1
R. A. Steinhardt
Affiliation:
Department of Zoology, University of California, Berkeley, CA 94720
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Extract

Developing cells have constantly to make decisions: when to proliferate and divide, when and how to differentiate. It is an increasingly attractive idea that these decisions involve changes in intracellular cation concentrations. Our ideas about the mechanisms of changes in intracellular cations come largely from the application of biophysical techniques in the study of excitable tissues. These ideas are proving very valuable to the investigation of the control of proliferation and cell development and it is evident that the ionic mechanisms which pertain in nerve and muscle have their counterparts in other cells. Just as alterations in intracellular ion concentrations serve a signalling function in excitable tissue, so too they act as signals during development. Since almost all the quantitative data on the ionic mechanisms of fertilization come from work on sea urchins we have confined our review to sea urchin eggs.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 15 , Issue 4 , November 1982 , pp. 593 - 666
Copyright
Copyright © Cambridge University Press 1982

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