Hostname: page-component-55f67697df-2mk96 Total loading time: 0 Render date: 2025-05-13T10:18:43.921Z Has data issue: false hasContentIssue false
  • English
  • Français

Dementia, deep white matter damage and hypertension: ‘Binswanger's disease’

Published online by Cambridge University Press:  09 July 2009

I. Janota
I. Janota*
Affiliation:
Department of Neutopathology, Institute of Psychiatry, London
*
1Address for correspondence: Dr I. Janota, Department of Neuropathology, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF.
Get access Rights & Permissions [Opens in a new window]

Synopsis

The clinical and neuropathological features are reported of 7 patients with organic intellectual impairment or dementia, hypertension and ischaemic destruction predominantly of the deep white matter of the cerebral hemispheres resembling that seen in infarction. The white matter changes have been dismissed as rare in the past, usually under the name of Binswanger's disease or subcortical arteriosclerotic encephalopathy, and without much concern for hypertension. There are now indications that this sort of case may not be uncommon. It can be suspected in life on CT scans. The accuracy of assessment of the pathological substrate of organic dementia, and therefore the strategies of research and treatment, might well benefit from further clinicopathological studies.

Type
Research Article
Information
Psychological Medicine , Volume 11 , Issue 1 , February 1981 , pp. 39 - 48
Copyright
Copyright © Cambridge University Press 1981

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

REFERENCES

Alzheimer, A. (1898). Neuere Arbeiten über die Dementia senilis und die auf atheromatöser Gefässerkrankung basierenden Gehirnkrankheiten. Monatsschrift für Psychiarie und Neurologie 3, 101–115.CrossRefGoogle Scholar
Alzheimer, A. (1902). Die Seelenstörungen auf arteriosklerotischer Grundlage. Allgemeine Zeitschrift für Psychiatrie undpsychischgerichtliche Medizin 59, 695–711.Google Scholar
Binswanger, O. (1894). Die Abgrenzung der allgemeinen progressiven Paralyse. Berliner klinische Wochenschrift 31, 1137–1139.Google Scholar
Binswanger, O. (1895). Die Begrenzung der aligemeinen progressiven Paralyse. Allgemeine Zeitschrift für Psychiatrie und psychischgerichtliche Medizin 51, 804–805.Google Scholar
Corsellis, J. A. N. (1962). Mental Illness and the Ageing Brain. The Distribution of Pathological Change in a Mental Hospital Population. Maudsley Monographs, no. 9. Oxford University Press: London.Google Scholar
Corsellis, J. A. N. (1969). The pathology of dementia. British Journal of Hospital Medicine 2, 695–702.Google Scholar
Delay, J. & Brion, S. (1962). Les démences tardives. Masson &Cie: Paris.Google Scholar
Feigin, L. & Popoff, N. (1963). Neuropathological changes late in cerebral oedema: the relationship to trauma, hypertensive disease and Binswanger's encephalopathy. Journal of Neuropathology and Experimental Neurology 22, 500–511.CrossRefGoogle ScholarPubMed
Garcin, R., Lapresle, J. & Lyon, G. (1960). Encéphalopathie sous-corticale chronique de Binswanger. Revue Neurologique 102,423–440.Google Scholar
Greenfield, J. G. (1938). Contribution to discussion on the presenile dementias: symptomatology, pathology, and differential diagnosis. Proceedings of the Royal Society of Medicine 31, 1450.Google Scholar
Hachinski, V. C., Lassen, N. A. & Marshall, J. (1974). Multi-infarct dementia. A cause of mental deterioration in the elderly. Lancet, 27 07, 207–210.CrossRefGoogle ScholarPubMed
Nissl, F. (1920). Zur Kasuistik der arteriosklerotischen Demenz: ein Fall von sogenannter Encephalitis Subcorticalis. Zeitschrift für die gesamte Neurologie und Psychiatrie 19, 438–443.Google Scholar
Ogata, J., Fujishima, M., Tamaki, K., Nakatomi, Y., Ishitsuka, T. & Omae, T. (1980). Stroke-prone spontaneously hypertensive rats as an experimental model of malignant hypertension. 1. A light- and electron-micro-scopic study of the brain. Acta neuropathologica (Berlin) 51, 179–184.CrossRefGoogle Scholar
Olszewski, J. (1962). Subcortical arteriosclerotic encephalopathy: review of the literature on the so-called Binswanger's disease and presentation of two cases. World Neurology 3, 359–375.Google ScholarPubMed
Sturm, K. & Zeumer, H. (1980). Binswanger's disease in computerogramm: a comparative clinical and morphological study. In First European Neuropathology Meeting Abstracts, no. 136, p.75. Facultas Verlag: Vienna.Google Scholar
Tomlinson, B. E. (1977). The pathology of dementia. In Dementia (ed. Wells, C. E.), pp. 113–153. F. A. Davis: Philadelphia.Google Scholar
Valentine, A. R., Moseley, I. F. & Kendall, B. E. (1980). White matter abnormality in cerebral atrophy: clinicoradiological correlations. Journal of Neurology, Neurosurgery, and Psychiatry 43, 139–142.Google ScholarPubMed