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The effect of betamethasone on Babesia microti and B. rodhaini infections in rodents

Published online by Cambridge University Press:  06 April 2009

A. S. Young  and
F. E. G. Cox
A. S. Young
Affiliation:
Department of Zoology, University of London King's College, London WC2R 2LS
F. E. G. Cox
Affiliation:
Department of Zoology, University of London King's College, London WC2R 2LS
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Extract

Seven daily injections of betamethasone given early in the infection adversely affect the immune response of rats and mice to Babesia microti and B. rodhaini. Betamethasone given late in the infection, when the parasitaemias are declining, causes recrudescences. The effects of betamethasone are reversible and those animals which survive the primary parasitaemia recover even if further courses of drug treatment are given. Betamethasone causes recrudescences of parasitaemia in some voles and field mice harbouring subpatent infections. Attention is drawn to the possibility that the therapeutic use of corticosteroids may enhance piroplasm infections and that elevated corticosteroid levels, resulting from stress situations, may affect latent piroplasmosis in wild caught rodents.

Type
Research Article
Information
Parasitology , Volume 63 , Issue 3 , December 1971 , pp. 447 - 453
Copyright
Copyright © Cambridge University Press 1971

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References

Cox, F. E. G. (1968). The effect of betamethasone on acquired immunity to Plaamodium vinckei in mice. Annals of Tropical Medicine and Parasitology 62, 295–300.CrossRefGoogle ScholarPubMed
Cox, F. E. G., Crandall, C. A. & Turner, S. A. (1969). Antibodies detected by the fluorescent antibody technique in mice infected with Plasmodium vinckei and P. chabaudi. Bulletin of the World Health Organisation 41, 251–60.Google ScholarPubMed
Cox, F. E. G. & Turner, S. A. (1970). Antibody levels in mice infected with Babesia microti. Annals of Tropical Medicine and Parasitology 64, 167–73.CrossRefGoogle ScholarPubMed
Cox, F. E. G. & Young, A. S. (1969). Acquired immunity to Babesia microti and Babesia rodhaini in mice. Parasitology 59, 257–68.CrossRefGoogle ScholarPubMed
Christian, J. J. (1959). The roles of endocrine and behavioural factors in the growth of mammalian populations. In Comparative endocrinology. Ed. A., Gorbman, pp. 71–97. New York: John Wiley.Google Scholar
Petana, W. B. (1964). Effects of cortisone upon the course of infection of Trypanosoma gambiense, T. rhodiense T. brucei and T. congolense in albino rats. Annals of Tropical Medicine and Parasitology 58, 192–8.CrossRefGoogle Scholar
Sherman, I. W. & Ruble, J. A. (1967). Virulent Trypanosoma lewisi infections in cortisone treated rats. Journal of Parasitology 53, 258–62.CrossRefGoogle ScholarPubMed
Stahl, W., Matsubayashi, H. & Akao, S. (1966). Modification of subclinical toxoplasmosis in mice by cortisone, 6-meroaptopurine and splenectomy. American Journal of Tropical Medicine and Hygiene 15, 869–74.CrossRefGoogle ScholarPubMed
Voller, A. (1964). Fluorescent antibody methods and their use in malaria research. Bulletin of the World Health Organization 30, 343–54.Google ScholarPubMed