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Anti-tick vaccines

Published online by Cambridge University Press:  19 April 2005

P. WILLADSEN
P. WILLADSEN
Affiliation:
CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, Queensland 4067, Australia
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Abstract

There is now abundant evidence that vaccination with defined protein antigens is able to induce significant immunity to tick infestation. In a limited number of cases, this immunity has been duplicated by vaccination with recombinant antigens, a critical step on the pathway to commercial vaccine production. The existence of two commercial vaccines has allowed a number of field studies showing that the existing products can make an important contribution to an integrated approach to the control of ticks in the field. Under most circumstances however, the use of a tick vaccine as the single, stand alone control technology is likely to require more efficacious vaccines than those currently available. Increases in efficacy are most likely to come through the discovery of additional, effective vaccine antigens. The number of antigens with demonstrated effect is increasing, though only slowly, while the number of potential antigens that remain to be evaluated is increasing more quickly. There is limited, though convincing, evidence that some of these antigens will show effective cross-species protection, though in a poorly understood and unpredictable way. The groundwork has been laid; the potential of the field is still to be effectively exploited.

Keywords

Boophilus microplusvaccineantigentick
Type
Research Article
Information
Parasitology , Volume 129 , Issue S1 , October 2004 , pp. S367 - S387
Copyright
© 2004 Cambridge University Press

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References

REFERENCES

ALJAMALI, M. N., BIOR, A. D., SAUER, J. R. & ESSENBERG, R. C. ( 2003). RNA interference in ticks: a study using histamine binding protein dsRNA in the female tick Amblyomma americanum. Insect Molecular Biology 12, 299–305.CrossRefGoogle Scholar
ALLEN, J. R. & HUMPHREYS, S. J. ( 1979). Immunisation of guinea pigs and cattle against ticks. Nature (London) 280, 491–493.CrossRefGoogle Scholar
ALMAZÁN, C., KOCAN, K. M., BERGMAN, D. K., GARCÍA-GARCÍA, J. C., BLOUIN, E. F. & DE LA FUENTE, J. (2003). Identification of protective antigens for the control of Ixodes scapularis infestations using cDNA expression library immunization. Vaccine 21, 1492–1501.CrossRefGoogle Scholar
ANDREOTTI, R., GOMES, A., MALAVAZI-PIZA, K. C., SASAKI, S. D., SAMPAIO, C. A. M. & TANAKA, A. S. ( 2002). BmTI antigens induce a bovine protective immune response against B. microplus tick. International Immunopharmacology 2, 557–563.CrossRefGoogle Scholar
ANDREOTTI, R., SAMPAIO, C. A. M., GOMES, A. & TANAKA, A. S. ( 1999). A serine proteinase inhibitor immunoprotection from B. microplus unfed larvae in calves. IV Seminario Internacional de Parasitologia Animal, 20–22 October, 1999, Puerto Vallarta, Jalisco, Mexico.
BARRIGA, O. O. ( 1999). Evidence and mechanisms of immunosuppression in tick infestations. Genetic Analysis – Biomolecular Engineering 15, 139–142.CrossRefGoogle Scholar
BERGMAN, D. K., PALMER, M. J., CAIMANO, M. J., RADOLF, J. D. & WIKEL, S. K. ( 2000). Isolation and molecular cloning of a secreted immunosuppressant protein from D. andersoni salivary gland. Journal of Parasitology 86, 516–525.Google Scholar
BISHOP, R., LAMBSON, B., WELLS, C., PANDIT, P., OSASO, J., NKONGE, C., MORZARIA, S., MUSOKE, A. & NENE, V. ( 2002). A cement protein of the tick Rhipicephalus appendiculatus, located in the secretory e cell granules of the type III salivary gland acini, induces strong antibody responses in cattle. International Journal for Parasitology 32, 833–842.CrossRefGoogle Scholar
CANALES, M., ENRIQUEZ, A., RAMOS, E., CABRERA, D., DANDIE, H., SOTO, A., FALCON, V., RODRIGUEZ, M. & DE LA FUENTE, J. ( 1997). Large-scale production in Pichia pastoris of the recombinant vaccine Gavac against the cattle tick. Vaccine 15, 414–422.CrossRefGoogle Scholar
COBON, G. S. ( 1997). An anti-arthropod vaccine: TickGARD – a vaccine to prevent cattle tick infestations. In New Generation Vaccines (ed. Levine, M. M., Woodrow, G. C., Kaper, J. B. & Cobon, G. S.), pp. 1145–1151. Marcel Dekker, Inc., New York, Basel, Hong Kong.
COBON, G. S., MOORE, J. T., JOHNSTON, L. A. Y., WILLADSEN, P., KEMP, D. H., SRISKANTHA, A., RIDING, G. A. & RAND, K. N. ( 1996). DNA encoding a cell membrane glycoprotein of a tick gut. US Patent and Trademark Office Appl. No. 325 071 435/240.2.
COBON, G. S. & WILLADSEN, P. ( 1990). Vaccines to prevent cattle tick infestations. In New Generation Vaccines (ed. Woodrow, G. C. & Levine, M. M.), pp. 901–917. Marcel Dekker, Inc., New York and Basel.
DA SILVA VAZ Jr., I., LOGULLO, C., SORGINE, M., VELLOSO, F. F., ROSA, D. E., LIMA, M. F., GONZALES, J. C., MASUDA, H., OLIVEIRA, P. L. & MASUDA, A. ( 1998). Immunization of bovines with an aspartic proteinase precursor isolated from B. microplus eggs. Veterinary Immunology and Immunopathology 66, 331–341.CrossRefGoogle Scholar
DAS, S., BANERJEE, G., DEPONTE, K., MARCANTONIO, N., KANTOR, F. S. & FIKRIG, E. ( 2001). Salp25D, an Ixodes scapularis antioxidant, is 1 of 14 immunodominant antigens in engorged tick salivary glands. Journal of Infectious Diseases 184, 1056–1064.CrossRefGoogle Scholar
DE LA FUENTE, J., RODRIGUEZ, M., MONTERO, C., REDONDO, M., GARCÍA-GARCÍA, J. C., MENDEZ, L., SERRANO, E., VALDES, M., ENRIQUEZ, A., CANALES, M., RAMOS, E., BOUE, O., MACHADO, H. & LLEONART, R. ( 1999). Vaccination against ticks (Boophilus spp.): the experience with the Bm86-based vaccine Gavac™. Genetic Analysis – Biomolecular Engineering 15, 143–148.Google Scholar
DE LA FUENTE, J., RODRIGUEZ, M., REDONDO, M., MONTERO, C., GARCÍA-GARCÍA, J. C., MENDEZ, L., SERRANO, E., VALDES, M., ENRIQUEZ, A., CANALES, M., RAMOS, E., BOUE, O., MACHADO, H., LLEONART, R., DE ARMAS, C. A., REY, S., RODRIGUEZ, J. L., ARTILES, M. & GARCIA, L. ( 1998). Field studies and cost-effectiveness of vaccination with Gavac against the cattle tick Boophilus microplus. Vaccine 16, 366–373.Google Scholar
DE ROSE, R., McKENNA, R. V., COBON, G., TENNENT, J., ZAKRZEWSKI, H., GALE, K., WOOD, P. R., SCHEERLINCK, J.-P. Y. & WILLADSEN, P. ( 1999). Bm86 antigen induces a protective immune response against B. microplus following DNA and protein vaccination in sheep. Veterinary Immunology and Immunopathology 71, 151–160.Google Scholar
DE VOS, S., ZEINSTRA, L., TAOUFIK, O., WILLADSEN, P. & JONGEJAN, F. ( 2001). Evidence for the utility of the Bm86 antigen from B. microplus in vaccination against other tick species. Experimental and Applied Acarology 25, 245–261.Google Scholar
DEL PINO, F. A. B., BRANDELLI, A., GONZALES, J. C., HENRIQUES, J. A. P. & DEWES, H. ( 1998). Effect of antibodies against β-N-acetylhexosaminidase on reproductive efficiency of the bovine tick B. microplus. Veterinary Parasitology 79, 247–255.CrossRefGoogle Scholar
FERREIRA, C. A. S., DA SILVA VAZ Jr., I., DA SILVA, S. S., HAAG, K. L., VALENZUELA, J. G. & MASUDA, A. ( 2002). Cloning and partial characterization of a Boophilus microplus (Acari: Ixodidae) calreticulin. Experimental Parasitology 101, 25–34.CrossRefGoogle Scholar
FERREIRA, B. R. & SILVA, J. S. ( 1998). Saliva of Rhipicephalus sanguineus tick impairs T cell proliferation and IFN-γ induced macrophage microbicidal activity. Veterinary Immunology and Immunopathology 64, 279–293.CrossRefGoogle Scholar
FERREIRA, B. R. & SILVA, J. S. ( 1999). Successive tick infestations selectively promote a T-helper 2 cytokine profile in mice. Immunology 96, 434–439.CrossRefGoogle Scholar
FRAGOSO, H., HOSHMAN-RAD, P., ORTIZ, M., RODRIGUES, M., REDONDO, M., HERRERA, L. & DE LA FUENTE, J. ( 1998). Protection against Boophilus annulatus infestations in cattle vaccinated with the B. microplus Bm86-containing vaccine Gavac. Vaccine 16, 1990–1992.Google Scholar
GARCÍA-GARCÍA, J. C., GONZALEZ, I. L., GONZALEZ, D. M., VALDÉS, M., MENDEZ, L., LAMBERTI, J., D'AGOSTINO, B., CITRONI, D., FRAGOSO, H., ORTIZ, M., RODRIGUEZ, M. & DE LA FUENTE, J. ( 1999). Sequence variations in the B. microplus Bm86 locus and implications for immunoprotection in cattle vaccinated with this antigen. Experimental and Applied Acarology 11, 883–895.Google Scholar
GARCÍA-GARCÍA, J. C., MONTERO, C., REDONDO, M., VARGAS, M., CANALES, M., BOUE, O., RODRIGUEZ, M., JOGLAR, M., MACHADO, H., GONZALEZ, I. L., VALDÉS, M., MENDEZ, L. & DE LA FUENTE, J. ( 2000). Control of ticks resistant to immunization with Bm86 in cattle vaccinated with the recombinant antigen Bm95 isolated from the cattle tick, B. microplus. Vaccine 18, 2275–2287.CrossRefGoogle Scholar
GARCÍA-GARCÍA, J. C., SOTO, A., NIGRO, F., MAZZA, M., JOGLAR, M., HECHEVARRÍA, M., LAMBERTI, J. & DE LA FUENTE, J. ( 1998). Adjuvant and immunostimulating properties of the recombinant Bm86 protein expressed in Pichia pastoris. Vaccine 16, 1053–1055.CrossRefGoogle Scholar
GILLESPIE, R. D., DOLAN, M. C., PIESMAN, J. & TITUS, R. G. ( 2001). Identification of an IL-2 binding protein in the saliva of the Lyme Disease vector tick, Ixodes scapularis. Journal of Immunology 166, 4319–4326.CrossRefGoogle Scholar
GOUGH, J. M. & KEMP, D. H. ( 1993). Localization of a low abundance membrane protein (Bm86) on the gut cells of the cattle tick B. microplus by immunogold labelling. Journal of Parasitology 79, 900–907.Google Scholar
GWAKISA, P., YOSHIHARA, K., TO, T. L., GOTOH, H., AMANO, F. & MOMOTANI, E. ( 2001). Salivary gland extract of Rhipicephalus appendiculatus ticks inhibits in vitro transcription and secretion of cytokines and production of nitric oxide by LPS-stimulated JA-4 cells. Veterinary Parasitology 99, 53–61.CrossRefGoogle Scholar
HAJNICKÁ, V., KOCÁKOVÁ, P., SLÁVIKOVÁ, M., GAšPERÍK, J., FUCHSBERGER, N. & NUTTALL, P. ( 2001). Anti-interleukin-8 activity of tick salivary gland extracts. Parasite Immunology 23, 483–489.CrossRefGoogle Scholar
HAMILTON, S. E., KEMP, D. H., McKENNA, R. V. & WILLADSEN, P. ( 1991). Gut cells of the tick B. microplus: the effect of vaccination on digest cells and experiments on blood meal absorption by these cells. In Modern Acarology. Vol. 1 (ed. Dusbabek, F. & Bukva, V.), pp. 341–351. SPB Academic Publishing, The Hague.
HANNIER, S., LIVERSIDGE, J., STERNBERG, J. M. & BOWMAN, A. S. ( 2003). Ixodes ricinus tick salivary gland extract inhibits IL-10 secretion and CD69 expression by mitogen-stimulated murine splenocytes and induces hyporesponsiveness in B lymphocytes. Parasite Immunology 25, 27–37.CrossRefGoogle Scholar
HUNGERFORD, J., PULGA, M., ZWTSCH, E. & COBON, G. ( 1995). Efficacy of TickGARD™ in Brazil. “Resistencia Y Control en Garrapatas Y Moscas de Importancia Veterinaria”, Seminario Internacional de Parasitologia Animal, 11–13 October, 1995, Sagar Canifarma FAO IICA INIFAP, Acapulco.
IWANAGA, S., OKADA, M., ISAWA, H., MORITA, A., YUDA, M. & CHINZEI, Y. ( 2003). Identification and characterization of novel salivary thrombin inhibitors from the Ixodidae tick, Haemaphysalis longicornis. European Journal of Biochemistry 270, 1926–1934.CrossRefGoogle Scholar
JARMEY, J. M., RIDING, G. A., PEARSON, R. D., McKENNA, R. V. & WILLADSEN, P. ( 1995). Carboxydipeptidase from B. microplus: a “concealed” antigen with similarity to angiotensin-converting enzyme. Insect Biochemistry and Molecular Biology 25, 969–974.Google Scholar
JASINSKAS, A., JAWORSKI, D. C. & BARBOUR, A. G. ( 2000). Amblyomma americanum: Specific uptake of immunoglobulins into tick hemolymph during feeding. Experimental Parasitology 96, 213–221.CrossRefGoogle Scholar
JAWORSKI, D. C., JASINSKAS, A., METZ, C. N., BUCALA, R. & BARBOUR, A. G. ( 2001). Identification and characterization of a homologue of the pro-inflammatory cytokine macrophage migration inhibitory factor in the tick, Amblyomma americanum. Insect Molecular Biology 10, 323–331.CrossRefGoogle Scholar
JAWORSKI, D. C., SIMMEN, F. A., LAMOREAUX, W., COONS, L. B., MULLER, M. T. & NEEDHAM, G. R. ( 1995). A secreted calreticulin protein in ixodid tick (Amblyomma americanum) saliva. Journal of Insect Physiology 41, 369–375.CrossRefGoogle Scholar
JONSSON, N. N., MAYER, D. G. & GREEN, P. E. ( 2000). Possible risk factors on Queensland dairy farms for acaricide resistance in cattle tick (B. microplus). Veterinary Parasitology 88, 79–92.CrossRefGoogle Scholar
JONSSON, N. N., MATSCHOSS, A. L., PEPPER, P., GREEN, P. E., ALBRECHT, M. S., HUNTERFORD, J. & ANSELL, J. ( 2000). Evaluation of TickGARD(PLUS), a novel vaccine against B. microplus, in lactating Holstein-Friesian cows. Veterinary Parasitology 88, 275–285.Google Scholar
JOUBERT, A. M., LOUW, A. I., JOUBERT, F. & NEITZ, A. W. H. ( 1998). Cloning, nucleotide sequence and expression of the gene encoding factor Xa inhibitor from the salivary glands of the tick, Ornithodoros savignyi. Experimental and Applied Acarology 22, 603–619.CrossRefGoogle Scholar
KARCZEWSKI, J., ENDRIS, R. & CONNOLLY, T. M. ( 1994). Disagregin is a fibrinogen receptor antagonist lacking the asp-gly-arg sequence from the tick, Ornithodoros moubata. Journal of Biological Chemistry 269, 6702–6708.Google Scholar
KEMP, D. H., AGBEDE, R. I. S., JOHNSTON, L. A. Y. & GOUGH, J. M. ( 1986). Immunization of cattle against B. microplus using extracts derived from adult female ticks. Feeding and survival of the parasite on vaccinated cattle. International Journal for Parasitology 16, 115–120.Google Scholar
KEMP, D. H., McKENNA, R. V., THULLNER, R. & WILLADSEN, P. ( 1999). Strategies for tick control in a world of acaricide resistance. Proceedings of the IV Seminario Internacional de Parasitologia Animal, pp. 1–10. Puerto Vallarta, Mexico October 20th–22nd, 1999.
KEMP, D. H., PEARSON, R. D., GOUGH, J. M. & WILLADSEN, P. ( 1989). Vaccination against B. microplus: localization of antigens on tick gut cells and their interaction with the host immune system. Experimental and Applied Acarology 7, 43–58.Google Scholar
KHALAF, A. S. S. ( 1999). Control of B. microplus ticks in cattle calves by immunization with a recombinant Bm86 glucoprotein antigen preparation. Deutsche Tierärztliche Wochenschrift 106, 248–251.Google Scholar
KITAICHI, K. J., OGASAWARA, K., IWABUCHI, K., NISHIHIRA, J., NAMBA, K. I., ONOE, K., KONISHI, J., KOTAKE, S., MATSUDA, H. & ONOE, K. ( 2000). Different influence of macrophage migration inhibitory factor (MIF) in signal transduction pathway of various T cell subsets. Immunobiology 201, 356–367.CrossRefGoogle Scholar
KOPECKY, J. & KUTHEJLOVA, M. ( 1998). Suppressive effect of I. ricinus salivary gland extract on mechanisms of natural immunity in vitro. Parasite Immunology 20, 169–174.Google Scholar
KOPECKY, J., KUTHEJLOVA, M. & PECHOVA, J. ( 1999). Salivary gland extract from I. ricinus ticks inhibits production of interferon-gamma by the upregulation of interleukin-10. Parasite Immunology 21, 351–356.Google Scholar
LABUDA, M., TRIMNELL, A. R., LICKOVA, M., KAZIMIROVA, M., SLOVAK, M. & NUTTALL, P. A. ( 2002). Recombinant tick salivary antigens (64TRP) as a TRANSBLOK vaccine against tick-borne encephalitis virus. Abstracts 4th International Conference on Ticks and Tick-Borne Pathogens, Banff, Canada, p. 51.
LAMBERTI, J., SIGNORINI, A., MATTOS, C., D'AGOSTINO, B., CITRONI, D., BACOS, E., RODRIGUEZ, M. & DE LA FUENTE, J. ( 1995). Evaluation of the recombinant vaccine against Boophilus microplus in grazing cattle in Argentina. In Recombinant Vaccines for the Control of the Cattle Tick (ed. De la Fuente, J.), pp. 205–227. Elfos Scientiae, La Habana, Cuba.
LAWRIE, C. H. & NUTTALL, P. A. ( 2001). Antigenic profile of I. ricinus: effect of developmental stage, feeding time and the response of different host species. Parasite Immunology 23, 549–556.Google Scholar
LAWRIE, C. H., RANDOLPH, S. E. & NUTTALL, P. A. ( 1999). Ixodes ticks: Serum species sensitivity of anticomplement activity. Experimental Parasitology 93, 207–214.CrossRefGoogle Scholar
LEBOULLE, G., CRIPPA, M., DECREM, Y., MEJRI, N., BROSSARD, M., BOLLEN, A. & GODFROID, E. ( 2002). Characterization of a novel salivary immunosuppressive protein from I. ricinus ticks. Journal of Biological Chemistry 277, 10083–10089.Google Scholar
LEE, R. P., JACKSON, L. A. & OPDEBEECK, J. P. ( 1991). Immune responses of cattle to biochemically modified antigens from the midgut of the cattle tick, B. microplus. Parasite Immunology 13, 661–672.CrossRefGoogle Scholar
LEE, R. P. & OPDEBEECK, J. P. ( 1991). Isolation of protective antigens from the gut of B. microplus using monoclonal antibodies. Immunology 72, 121–126.Google Scholar
LIYOU, N. ( 1996). An investigation of the 5′-nucleotidase from the cattle tick B. microplus. PhD thesis. University of Queensland, St. Lucia, Australia.
LIYOU, N., HAMILTON, S., ELVIN, C. & WILLADSEN, P. ( 1999). Cloning and expression of ecto 5′-nucleotidase from the cattle tick B. microplus. Insect Molecular Biology 8, 257–266.CrossRefGoogle Scholar
LIYOU, N., HAMILTON, S., McKENNA, R., ELVIN, C. & WILLADSEN, P. ( 2000). Localisation and functional studies on the 5′-nucleotidase of the cattle tick B. microplus. Experimental and Applied Acarology 24, 235–246.CrossRefGoogle Scholar
LODOS, J., BOUE, O. & DE LA FUENTE, J. ( 2000). A model to simulate the effect of vaccination against Boophilus ticks on cattle. Veterinary Parasitology 87, 315–326.CrossRefGoogle Scholar
LODOS, J., OCHAGAVIA, M. E., RODRIGUEZ, M. & DE LA FUENTE, J. ( 1999). A simulation study of the effects of acaricides and vaccination on Boophilus cattle-tick populations. Preventative Veterinary Medicine 38, 47–63.CrossRefGoogle Scholar
LOGULLO, C., MORAES, J., DANSA-PETRETSKI, M., VAZ Jr., I. S., MASUDA, A., SORGINE, M. H. F., BRAZ, G. R., MATSUDA, H. & OLIVEIRA, P. L. ( 2002). Binding and storage of heme by vitellin from the cattle tick, B. microplus. Insect Biochemistry and Molecular Biology 32, 1805–1811.CrossRefGoogle Scholar
MANS, B. J., LOUW, A. I. & NEITZ, A. W. H. ( 2002). Disaggregation of aggregated platelets by savignygrin, an αIIbβ3 antagonist from Ornithodoros savignyi. Experimental and Applied Acarology 27, 231–239.CrossRefGoogle Scholar
McKENNA, R. V., RIDING, G. A., JARMEY, J. M., PEARSON, R. D. & WILLADSEN, P. ( 1998). Vaccination of cattle against the tick B. microplus using a mucin-like membrane glycoprotein. Parasite Immunology 20, 325–336.Google Scholar
MONTESINO, R., CREMATA, J., RODRIGUEZ, M., BESADA, V., FALCON, V. & DE LA FUENTE, J. ( 1996). Biochemical characterization of the recombinant B. microplus Bm86 antigen expressed by transformed Pichia pastoris cells. Biotechnology and Applied Biochemistry 23, 23–28.Google Scholar
MONZAVI-KARBASSI, B., CUNTO-AMESTY, G., LUO, P. & KIEBER-EMMONS, T. ( 2002). Peptide momotopes as surrogate antigens of carbohydrates in vaccine discovery. Trends in Biotechnology 20, 207–214.CrossRefGoogle Scholar
MULENGA, A., SUGINO, M., NAKAJIMA, M., SUGIMOTO, C. & ONUMA, M. ( 2001). Tick-encoded serine proteinase inhibitors (Serpins); potential target antigens for tick vaccine development. Journal of Veterinary Medical Science 63, 1063–1069.CrossRefGoogle Scholar
MULENGA, A., SUGIMOTO, C., SAKO, Y., OHASHI, K., MUSOKE, A., MOZARIA, S. & ONUMA, M. ( 1999). Molecular characterization of a Haemaphysalis longicornis tick salivary gland-associated 29-kilodalton protein and its effect as a vaccine against tick infestation in rabbits. Infection and Immunity 67, 1652–1658.Google Scholar
MULENGA, A., SUGIMOTO, C., OHASHI, K. & ONUMA, M. ( 2000). Characterization of an 84 kDa protein inducing an immediate hypersensitivity reaction in rabbits sensitised to Haemaphysalis longicornis ticks. Biochimica et Biophysica Acta-Molecular Basis of Disease 1501, 219–226.CrossRefGoogle Scholar
MULENGA, A., TSUDA, A., ONUMA, M. & SUGIMOTO, C. ( 2003). Four serine proteinase inhibitors (serpin) from the brown ear tick, Rhipicephalus appendiculatus; cDNA cloning and preliminary characterization. Insect Biochemistry and Molecular Biology 33, 267–276.CrossRefGoogle Scholar
MULENGA, A., TSUDA, A., SUGIMOTO, C. & ONUMA, M. ( 2002). Blood meal acquisition by ticks; molecular advances and implications for vaccine development. Japanese Journal of Veterinary Research 49, 261–272.Google Scholar
NAKAJIMA, M., YANASE, H., IWANAGA, T., KODAMA, M., OHASHI, K. & ONUMA, M. ( 2003). Passive immunization with monoclonal antibodies: effects on Haemaphysalis longicornis tick infestation of BALB/c mice. Japanese Journal of Veterinary Research 50, 157–163.Google Scholar
NENE, V., LEE, D., QUACKENBUSH, J., SKILTON, R., MWAURA, S., GARDNER, M. J. & BISHOP, R. ( 2002). AvGI, an index of genes transcribed in the salivary glands of the ixodid tick Amblyomma variegatum. International Journal for Parasitology 32, 1447–1456.CrossRefGoogle Scholar
OLIVEIRA, M. F., SILVA, J. R., DANSA-PETRETSKI, M., DE SOUZA, W., LINS, U., BRAGA, C. M. S., MASUDA, H. & OLIVEIRA, P. ( 1999). Haem detoxification of by an insect. Nature 400, 517–518.CrossRefGoogle Scholar
PACKILA, M. & GUILFOILE, P. G. ( 2002). Mating, male Ixodes scapularis express several genes including those with sequence similarity to immunoglobulin-binding proteins and metalloproteases. Experimental and Applied Acarology 27, 151–160.CrossRefGoogle Scholar
PAESEN, G. C., ADAMS, P. L., HARLOS, K., NUTTALL, P. A. & STUART, D. I. ( 1999). Tick histamine-binding proteins: isolation cloning and three-dimensional structure. Molecular Cell 3, 661–671.CrossRefGoogle Scholar
PAESEN, G. C., ADAMS, P. L., NUTTALL, P. A. & STUART, D. I. ( 2000). Tick histamine-binding proteins: lipocalins with a second binding cavity. Biochimica et Biophysica Acta 1482, 92–101.CrossRefGoogle Scholar
PATARROYO, J. H., PORTELA, R. W., DE CASTRO, R. O., COUTO PIMENTEL, J., GUZMAN, F., PATARROYO, M. E., VARGAS, M. I., PRAATES, A. A. & DIAS MENDES, M. A. ( 2002). Immunization of cattle with synthetic peptides derived from the B. microplus gut protein (Bm86). Veterinary Immunology and Immunopathology 88, 163–172.CrossRefGoogle Scholar
PIPANO, E., ALEKCEEV, E., GALKER, F., FISH, L., SAMISH, M. & SHKAP, V. ( 2003). Immunity against Boophilus annulatus induced by the Bm86 (Tick-GARD) vaccine. Experimental and Applied Acarology 29, 141–149.CrossRefGoogle Scholar
PRUETT, J. H. ( 1999). Immunological control of arthropod ectoparasites – a review. International Journal for Parasitology 29, 25–32.CrossRefGoogle Scholar
RAND, K. N., MOORE, T., SRISKANTHA, A., SPRING, K., TELLAM, R., WILLADSEN, P. & COBON, G. S. ( 1989). Cloning and expression of a protective antigen from the cattle tick B. microplus. Proceedings of the National Academy of Sciences, USA 86, 9657–9661.CrossRefGoogle Scholar
REDONDO, M., FRAGOSO, H., ORTIZ, M., MONTERO, C., LONA, J., MEDELLIN, J. A., FRIA, R., HERNANDEZ, V., FRANCO, R., MACHADO, H., RODRÍGUEZ, M. & DE LA FUENTA, J. ( 1999). Integrated control of acaricide-resistant B. microplus populations on grazing cattle in Mexico using vaccination with Gavac™ and amidine treatments. Experimental and Applied Acarology 23, 841–849.Google Scholar
RICHARDSON, M. A., SMITH, D. R. J., KEMP, D. H. & TELLAM, R. L. ( 1993). Native and baculovirus-expressed forms of the immunoprotective protein Bm86 from B. microplus are anchored to the cell membrane by a glycosylphosphatidyl inositol linkage. Insect Molecular Biology 1, 139–147.Google Scholar
RIDING, G., JARMEY, J., McKENNA, R. V., PEARSON, R., COBON, G. S. & WILLADSEN, P. ( 1994). A protective “concealed” antigen from B. microplus: purification, localization and possible function. Journal of Immunology 153, 5158–5166.Google Scholar
RODRÍGUEZ, M., MASSARD, C. L., HENRIQUE DA FONSECA, A., RAMOS, N. F., MACHADO, H., LABARTA, V. & DE LA FUENTE, J. ( 1995 a). Effect of a vaccination with a recombinant Bm86 antigen preparation on natural infestations of B. microplus in grazing dairy and beef pure and cross-bred cattle in Brazil. Vaccine 13, 1804–1808.Google Scholar
RODRÍGUEZ, M., PENICHET, M. L., MOURIS, A. E., LABARTA, V., L., LORENZO LUACES, RUBIERA, R., CORDOVÉS, C., SÁNCHEZ, P. A., RAMOS, E., SOTO, A., CANALES, M., PALENZUELA, D., TRIIGUERO, A., LLEONART, R., HERRERA, L. & DE LA FUENTE, J. ( 1995 b). Control of B. microplus populations in grazing cattle vaccinated with a recombinant Bm86 antigen preparation. Veterinary Parasitology 57, 339–349.Google Scholar
RODRÍGUEZ, M., RUBIERA, R., PENICHET, M. L., MONTESINOS, R., CREMATA, J., FALCON, V., SÁNCHEZ, P. A., CORDOVÉS, C., VALDÉS, M., LLEONART, R., HERRERA, L. & DE LA FUENTE, J. ( 1994). High level expression of the B. microplus Bm86 antigen in the yeast Pichia pastoris forming highly immunogenic particles for cattle. Journal of Biotechnology 33, 135–146.Google Scholar
SANGAMNATDEJ, S., PAESEN, G. C., SLOVAK, M. & NUTTALL, P. A. ( 2002). A high affinity seretonin- and histamine-binding lipocalin from tick saliva. Insect Molecular Biology 11, 79–86.CrossRefGoogle Scholar
SATOSKAR, A. R., BOZZA, M., RODRIGUEZ, S. M., GUOSHING, L. & DAVID, J. R. ( 2001). Migration-inhibitory factor gene-deficient mice are susceptible to cutaneous Leishmania major infection. Infection and Immunity 69, 906–911.CrossRefGoogle Scholar
SAUER, J. R., McSWAIN, J. L. & ESSENBERG, R. C. ( 1994). Cell membrane receptors and regulation of cell function in ticks and blood-sucking insects. International Journal for Parasitology 24, 33–52.CrossRefGoogle Scholar
SHARMA, J. K., GHOSH, G., KHAN, M. H. & DAS, G. ( 2001). Immunoprotective efficacy of a purified 39 kDa nymphal antigen of Hyalomma anatolicum anatolicum. Tropical Animal Health and Production 33, 103–116.CrossRefGoogle Scholar
SITTE, K., BRINKWORTH, R., EAST, I. J. & JAZWINSKA, E. C. ( 2002). A single amino acid deletion in the antigen binding site of BoLA-DRB3 is predicted to affect peptide binding. Veterinary Immunology and Immunopathology 85, 129–135.CrossRefGoogle Scholar
SUGINO, M., IMAMURA, S., MULENGA, A., NAKAJIMA, M., TSUDA, A., OHASHI, K. & ONUMA, M. ( 2003). A serine proteinase inhibitor (serpin) from the ixodid tick Haemaphysalis longicornis; cloning, and preliminary assessment of its suitability as a candidate for a tick vaccine. Vaccine 21, 2844–2851.CrossRefGoogle Scholar
TANAKA, A. S., ANDREOTTI, R., GOMES, A., TORQUATO, R. J. S., SAMPAIO, M. U. & SAMPAIO, C. A. M. ( 1999). A double headed serine proteinase inhibitor – human plasma kallikrein and elastase inhibitor – from B. microplus larvae. Immunopharmacology 45, 171–177.CrossRefGoogle Scholar
TELLAM, R. L., KEMP, D., RIDING, G., BRISCOE, S., SMITH, P., SHARP, P., IRVING, D. & WILLADSEN, P. ( 2002). Reduced oviposition of B. microplus feeding on sheep vaccinated with vitellin. Veterinary Parasitology 103, 141–156.Google Scholar
TELLAM, R. L., SMITH, D., KEMP, D. H. & WILLADSEN, P. ( 1992). Vaccination against ticks. In Animal Parasite Control Utilizing Biotechnology (ed. Yong, W. K.), pp. 303–331. CRC Press, Boca Raton.
TRIMNELL, A. R., HAILS, R. S. & NUTTALL, P. A. ( 2002). Dual action ectoparasite vaccine targeting ‘exposed’ and ‘concealed’ antigens. Vaccine 20, 3360–3568.CrossRefGoogle Scholar
TSUDA, A., MULENGA, A., SUGIMOTO, C., NAKAJIMA, M., OHASHI, K. & ONUMA, M. ( 2001). cDNA cloning, characterization and vaccine effect analysis of Haemaphysalis longicornis tick saliva proteins. Vaccine 19, 4287–4296.CrossRefGoogle Scholar
TURNBULL, I. F., SMITH, D. R. J., SHARP, P. J., COBON, G. S. & HYNES, M. J. ( 1990). Expression and secretion in Aspergillus nidulans and Aspergillus niger of a cell surface glycoprotein from the cattle tick B. microplus, by using the fungal amdS promoter system. Applied and Environmental Microbiology 56, 2847–2852.Google Scholar
VALENZUELA, J. G., CHARLAB, R., MATHER, T. N. & RIBEIRO, J. M. C. ( 2000). Purification, cloning, and expression of a novel salivary anticomplement protein from the tick, Ixodes scapularis. Journal of Biological Chemistry 275, 18717–18723.CrossRefGoogle Scholar
VAUGHAN, J. A., SONENSHINE, D. E. & AZAD, A. F. ( 2002). Kinetics of ingested host immunoglobulin G in hemolymph and whole body homogenates during nymphal development of Dermacentor variabilis and Ixodes scapularis ticks (Acari: Ixodidae). Experimental and Applied Acarology 27, 329–340.CrossRefGoogle Scholar
WANG, H. & NUTTALL, P. A. ( 1994 a). Comparison of the proteins in salivary glands, saliva and haemolymph of Rhipicephalus appendiculatus female ticks during feeding. Parasitology 109, 517–523.Google Scholar
WANG, H. & NUTTALL, P. A. ( 1994 b). Excretion of host immunoglobulin in tick saliva and detection of IgG-binding proteins in tick haemolymph and salivary glands. Parasitology 109, 525–530.Google Scholar
WANG, H. & NUTTALL, P. A. ( 1999). Immunoglobulin-binding proteins in ticks: new target for vaccine development against a blood-feeding parasite. Cellular and Molecular Life Sciences 56, 286–295.CrossRefGoogle Scholar
WANG, X., COONS, L. B., TAYLOR, D. B., STEVENS, J. E. Jr. & GARTNER, T. K. ( 1996). Variabilin, a novel RGD-containing antagonist of glycoprotein Iib-IIIa and platelet aggregation inhibitor from the hard tick Dermacentor variabilis. Journal of Biological Chemistry 271, 17785–17790.CrossRefGoogle Scholar
WIKEL, S. ( 1999). Tick modulation of host immunity: an important factor in pathogen transmission. International Journal for Parasitology 29, 851–859.CrossRefGoogle Scholar
WIKEL, S. K. & ALARCON-CHAIDEZ, F. J. ( 2001). Progress toward molecular characterization of ectoparasite modulation of host immunity. Veterinary Parasitology 101, 275–287.CrossRefGoogle Scholar
WILLADSEN, P. & RIDING, G. A. ( 1979). Characterization of a proteolytic-enzyme inhibitor with allergenic activity. Multiple functions of a parasite-derived protein. Biochemical Journal 177, 41–47.Google Scholar
WILLADSEN, P. ( 1980). Immunity to ticks. Advances in Parasitology 18, 293–313.CrossRefGoogle Scholar
WILLADSEN, P. ( 1997). Novel vaccines for ectoparasites. Veterinary Parasitology 71, 209–222.CrossRefGoogle Scholar
WILLADSEN, P. ( 2001). The molecular revolution in the development of vaccines against ectoparasites. Veterinary Parasitology 101, 353–367.CrossRefGoogle Scholar
WILLADSEN, P. & BILLINGSLEY, P. F. ( 1997). Immune intervention against blood-feeding insects. In The Biology of the Insect Midgut (ed. Lehane, M. J. & Billingsley, P. F.), pp. 323–343. Chapman & Hall, London.
WILLADSEN, P., BIRD, P., COBON, G. S. & HUNGERFORD, J. ( 1995). Commercialisation of a recombinant vaccine against B. microplus. Parasitology 110, 43–50.CrossRefGoogle Scholar
WILLADSEN, P. & JONGEJAN, F. ( 1999). Immunology of the tick–host interaction and the control of ticks and tick-borne diseases. Parasitology Today 15, 258–262.CrossRefGoogle Scholar
WILLADSEN, P., KEMP, D. H. & McKENNA, R. V. ( 1984). Bloodmeal ingestion and utilization as a component of host specificity in the tick, B. microplus. Zeitschrift für Parasitenkunde 70, 415–420.CrossRefGoogle Scholar
WILLADSEN, P. & KEMP, D. H. ( 1988). Vaccination with ‘concealed’ antigens for tick control. Parasitology Today 4, 196–198.CrossRefGoogle Scholar
WILLADSEN, P. & McKENNA, R. V. ( 1983). Trypsin chymotrypsin inhibitors from the parasitic tick. Australian Journal of Experimental Biological and Medical Science 61, 231–238.CrossRefGoogle Scholar
WILLADSEN, P. & McKENNA, R. V. ( 1991). Vaccination with ‘concealed’ antigens: myth or reality? Parasite Immunology 13 605–616.Google Scholar
WILLADSEN, P., McKENNA, R. V. & RIDING, G. A. ( 1988). Isolation from the cattle tick, B. microplus, of antigenic material capable of eliciting a protective immunological response in the bovine host. International Journal for Parasitology 18, 183–189.Google Scholar
WILLADSEN, P. & RIDING, G. A. ( 1980). On the biological role of a proteolytic-enzyme inhibitor from the ectoparasitic tick B. microplus. Biochemical Journal 189, 295–303.Google Scholar
WILLADSEN, P., RIDING, G. A., McKENNA, R. V., KEMP, D. H., TELLAM, R. L., NIELSEN, J. N., LAHNSTEIN, J., COBON, G. S. & GOUGH, J. M. ( 1989). Immunologic control of a parasitic arthropod. Identification of a protective antigen from B. microplus. Journal of Immunology 143, 1346–1351.Google Scholar
WILLADSEN, P., SMITH, D., COBON, G. & McKENNA, R. V. ( 1996). Comparative vaccination of cattle against B. microplus with recombinant antigen Bm86 alone or in combination with recombinant Bm91. Parasite Immunology 18, 241–246.Google Scholar