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Synthesis and Characterization of Periodic Polypeptides Containing Repeating —(AlaGly)xGluGly— Sequences

Published online by Cambridge University Press:  15 February 2011

Yoshikuni Deguchi ,
Mark T. Krejchi ,
Janos Borbely ,
Maurille J. Fournier ,
Thomas L. Mason  and
David A. Tirrell
Yoshikuni Deguchi
Affiliation:
Department of Polymer Science and Engineering, University of Massachusetts, Amherst, Massachusetts 01003
Mark T. Krejchi
Affiliation:
Department of Polymer Science and Engineering, University of Massachusetts, Amherst, Massachusetts 01003
Janos Borbely
Affiliation:
Department of Polymer Science and Engineering, University of Massachusetts, Amherst, Massachusetts 01003
Maurille J. Fournier
Affiliation:
Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts 01003
Thomas L. Mason
Affiliation:
Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts 01003
David A. Tirrell
Affiliation:
Department of Polymer Science and Engineering, University of Massachusetts, Amherst, Massachusetts 01003
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Abstract

We have expressed in E. coli a series of periodic polypeptides represented by sequence 1. Our objective has been an understanding of the role of chemical sequence in determining the chain folding behavior of periodic macromolecules. Molecular organization has been examined by infrared spectroscopy and 1H and 13C NMR methods and a preliminary model of the folded structure has been developed.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 292: Symposium S – Biomolecular Materials , 1992 , 205
Copyright
Copyright © Materials Research Society 1993

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References

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