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CSF monoamine metabolites and neuropeptides in depressed patients before and after electroconvulsive therapy

Published online by Cambridge University Press:  16 April 2020

Georg Nikisch  and
Aleksander A. Mathé
Georg Nikisch*
Affiliation:
Department of Psychiatry and Psychotherapy, Klinikum Fulda gAG, Pacelliallee 4, D-36043Fulda, Germany
Aleksander A. Mathé
Affiliation:
Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Karolinska University Hospital, Huddinge SE-141 86Stockholm, Sweden
*
*Corresponding author. Tel.: +49 661 84 5736; fax: +49 661 84 5722. E-mail address: [email protected] (G. Nikisch).
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Abstract

Antidepressant drugs affect monoamines and neuropeptides in human cerebrospinal fluid (CSF) and in rodent brain. The purpose of this study was to investigate if also electroconvulsive therapy (ECT) affects these compounds in a similar manner in the CSF of depressed patients. Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and corticotropin-releasing hormone (CRH)-like immunoreactivity (-LI) and neuropeptide Y (NPY)-LI were determined in CSF in six drug resistant patients with major depression. Lumbar puncture was performed at baseline and after completion of eight ECTs. ECT was associated with an increase in NPY-LI (p = 0.009) and a decrease in CRH-LI (p ≤ 0.001). HVA (p = 0.003) and 5-HIAA (p = 0.002) were significantly increased after the ECT. Findings of NPY increase and CRH decrease were similar to those following chronic treatment with citalopram, indicating that these changes might constitute one of the common underpinnings of antidepressant treatment modalities.

Keywords

Monoamine metabolitesNeuropeptidesECTMajor depressionCSF
Type
Short communication
Information
European Psychiatry , Volume 23 , Issue 5 , August 2008 , pp. 356 - 359
Copyright
Copyright © Elsevier Masson SAS 2008

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