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Resting-state alterations in emotion salience and default-mode network connectivity in atypical trajectories of psychotic-like experiences

Published online by Cambridge University Press:  19 September 2024

Roxane Assaf ,
Julien Ouellet ,
Josiane Bourque ,
Emmanuel Stip ,
Marco Leyton ,
Patricia Conrod  and
Stéphane Potvin Open the ORCID record for Stéphane Potvin [Opens in a new window]
Roxane Assaf
Affiliation:
Centre de Recherche de l’Institut Universitaire en Santé Mentale De Montréal, Montreal, QC, Canada Department of Psychiatry and Addiction, Faculty of Medicine, University of Montreal, Montreal, QC, Canada
Julien Ouellet
Affiliation:
Department of Psychiatry and Addiction, Faculty of Medicine, University of Montreal, Montreal, QC, Canada Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada
Josiane Bourque
Affiliation:
Department of Psychiatry, Perelman Faculty of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Emmanuel Stip
Affiliation:
Department of Psychiatry and Addiction, Faculty of Medicine, University of Montreal, Montreal, QC, Canada
Marco Leyton
Affiliation:
Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC, Canada
Patricia Conrod
Affiliation:
Department of Psychiatry and Addiction, Faculty of Medicine, University of Montreal, Montreal, QC, Canada Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada
Stéphane Potvin*
Affiliation:
Centre de Recherche de l’Institut Universitaire en Santé Mentale De Montréal, Montreal, QC, Canada Department of Psychiatry and Addiction, Faculty of Medicine, University of Montreal, Montreal, QC, Canada
*
Corresponding author: Stéphane Potvin; Email: [email protected]
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Abstract

Social cognition is commonly altered in people with psychosis. Two main brain networks have been implicated: the default-mode network (DMN), which is associated with socio-cognitive processing, and the salience network (SN) associated with socio-affective processing. Disturbances to the resting-state functional connectivity of these networks have been identified in schizophrenia and high-risk individuals, but there have been no studies in adolescents displaying distinct trajectories of subclinical psychotic-like experiences (PLEs). To address this, the present study measured SN and DMN resting-state connectivity in a unique longitudinally followed sample of youth (n = 92) presenting with typical and atypical 4-year PLE trajectories. Compared to the typically developing low PLE control group, the atypical increasing PLE trajectory displayed reduced connectivity between the SN and DMN, increased connectivity between left and right insula, and widespread dysconnectivity from the insula and amygdala. These alterations are similar to those reported in schizophrenia and clinical high-risk samples, suggesting that early detection may be useful for mapping the developmental trajectories of psychotic disorders.

Keywords

psychosis riskpsychotic experiencesneuroimagingresting state
Type
Regular Article
Information
Development and Psychopathology , First View , pp. 1 - 10
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© The Author(s), 2024. Published by Cambridge University Press

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