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Availability of dopamine transporters and auditory P300 abnormalities in adults with attention-deficit hyperactivity disorder: preliminary results

Published online by Cambridge University Press:  29 August 2017

Ching-Lin Chu ,
I Hui Lee ,
Mei Hung Chi ,
Kao Chin Chen ,
Po See Chen ,
Wei Jen Yao ,
Nan Tsing Chiu  and
Yen Kuang Yang
Ching-Lin Chu
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
I Hui Lee
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
Mei Hung Chi*
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Kao Chin Chen
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
Po See Chen
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
Wei Jen Yao
Affiliation:
Department of Nuclear Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Nan Tsing Chiu
Affiliation:
Department of Nuclear Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Yen Kuang Yang
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
*
*Address correspondence and reprint requests to: Mei Hung Chi, Department of Psychiatry, National Cheng Kung University Hospital, 138 Sheng Li Road, North District, Tainan 704, Taiwan. (Email: [email protected])
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Abstract

Objective

Previous studies have indicated that there is dopamine transporter (DAT) dysregulation and P300 abnormality in adults with attention-deficit hyperactivity disorder (ADHD); however, the correlations among the three have not been fully explored.

Methods

A total of 11 adults (9 males and 2 females) with ADHD and 11 age-, sex-, and education-level-matched controls were recruited. We explored differences in DAT availability using single-photon emission computed tomography and P300 wave of event-related potentials between the two groups. The correlation between DAT availability and P300 performance was also examined.

Results

DAT availability in the basal ganglia, caudate nucleus, and putamen was significantly lower in the ADHD group. Adults with ADHD had lower auditory P300 amplitudes at the Pz and Cz sites, as well as longer Fz latency than controls. DAT availability was negatively correlated to P300 latency at Pz and Fz.

Conclusions

Adults with ADHD had both abnormal DAT availability and P300 amplitude, suggesting that ADHD is linked to dysfunction of the central dopaminergic system and poor cognitive processes related to response selection and execution.

Keywords

Attention-deficit hyperactivity disorderadultdopamine transporterP300SPECT
Type
Original Research
Information
CNS Spectrums , Volume 23 , Issue 4 , August 2018 , pp. 264 - 270
Copyright
© Cambridge University Press 2017 

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