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Task-State Functional MRI of Brain Regions with Reduced Activation in Aphasia Patients: A Meta-analysis

Published online by Cambridge University Press:  03 October 2024

Xin-ming Yu Open the ORCID record for Xin-ming Yu [Opens in a new window] ,
Wen-ming Lv ,
Qiao-wen Yu ,
Xi-zhi Kang ,
Xiao-liang Liu  and
Liang-wen Zhang Open the ORCID record for Liang-wen Zhang [Opens in a new window]
Xin-ming Yu
Affiliation:
Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, SD, China Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, SD, China
Wen-ming Lv
Affiliation:
Department of Neurosurgery, First People’s Hospital of Ningyang County, Tai’an, SD, China
Qiao-wen Yu
Affiliation:
Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, SD, China Department of Medical Imaging, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, SD, China
Xi-zhi Kang
Affiliation:
Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, SD, China Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, SD, China
Xiao-liang Liu*
Affiliation:
Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, SD, China Cancer Institute, Qingdao Cancer Institute, Qingdao University, Qingdao, SD, China
Liang-wen Zhang*
Affiliation:
Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, SD, China Shandong Institute of Brain Science and Brain-inspired Research, Jinan, SD, China
*
Corresponding authors: Xiao-liang Liu; Email: [email protected]; Liang-wen Zhang; Email: [email protected]
Corresponding authors: Xiao-liang Liu; Email: [email protected]; Liang-wen Zhang; Email: [email protected]
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Abstract

Objective:

Language is one of the most celebrated hallmarks of human cognition. With the continuous improvement of medical technology, functional MRI (fMRI) has been used in aphasia. Although many related studies have been carried out, most studies have not extensively focused on brain regions with reduced activation in aphasic patients. The aim of this study was to identify brain regions normally activated in healthy controls but with reduced activation in aphasic patients during fMRI language tasks.

Methods:

We collected all previous task-state fMRI studies of secondary aphasia. The brain regions showed normal activation in healthy controls and reduced activation in aphasic patients were conducted activation likelihood estimation (ALE) meta-analysis to obtain the brain regions with consistently reduced activation in aphasic patients.

Results:

The ALE meta-analysis revealed that the left inferior frontal gyrus, left middle temporal gyrus, left superior temporal gyrus, left fusiform gyrus, left lentiform nucleus and the culmen of the cerebellum were the brain regions with reduced activation in aphasic patients.

Discussion:

These findings from the ALE meta-analysis have significant implications for understanding the language network and the potential for recovery of language functions in individuals with aphasia.

Résumé

RÉSUMÉ

IRMf en cours de tâche des régions cérébrales à activation réduite chez des patients aphasiques: une méta-analyse

Objectif :

Le langage est l’une des caractéristiques les plus renommées de la cognition humaine. Avec l’amélioration continue de la technologie médicale, l’IRM fonctionnelle (IRMf) est désormais utilisée dans le cas de l’aphasie. Bien que de nombreuses études connexes aient été réalisées, la plupart d’entre elles n’ont pas porté sur les régions du cerveau de patients aphasiques dont l’activation est réduite. L’objectif de cette étude était donc d’identifier, lors de tâches linguistiques analysées par IRMf, les régions cérébrales normalement activées chez des témoins sains et celles dont l’activation était réduite chez des patients aphasiques.

Méthodes :

Nous avons rassemblé toutes les études antérieures d’IRMf de l’aphasie secondaire. Les régions cérébrales présentant une activation normale chez des témoins sains et une activation réduite chez des patients aphasiques ont fait l’objet d’une méta-analyse de l’estimation de la vraisemblance de l’activation (EVA) afin de déterminer les régions cérébrales présentant une activation réduite constante chez des patients aphasiques.

Résultats :

La méta-analyse de l’EVA a révélé que le gyrus frontal inférieur gauche, le gyrus temporal moyen gauche, le gyrus temporal supérieur gauche, le gyrus fusiforme gauche, le noyau lenticulaire gauche et le culmen du cervelet étaient les régions cérébrales présentant une activation réduite chez les patients aphasiques.

Discussion :

En somme, ces résultats de la méta-analyse de l’EVA ont des implications significatives pour la compréhension du réseau du langage et la récupération potentielle des fonctions langagières chez les patients aphasiques.

Keywords

Aphasiameta-analysistask-state fMRI
Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 52 , Issue 3 , May 2025 , pp. 442 - 449
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of Canadian Neurological Sciences Federation

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