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Obesity and risk for liver disease: a two-sample Mendelian randomisation study

Published online by Cambridge University Press:  06 November 2024

Wen An Open the ORCID record for Wen An [Opens in a new window] ,
Jing Luo ,
Zhe Yu ,
Mengqi Li ,
Herui Wei ,
Aqian Song ,
Yuanpeng Mao ,
Hao Bian ,
Lingling He  and
Fan Xiao
...Show all authors
Wen An
Affiliation:
Department of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, People’s Republic of China
Jing Luo
Affiliation:
Department of Gastroenterology, Peking University Ditan Teaching Hospital, Beijing 100015, People’s Republic of China
Zhe Yu
Affiliation:
Department of Gastroenterology, Peking University Ditan Teaching Hospital, Beijing 100015, People’s Republic of China
Mengqi Li
Affiliation:
Department of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, People’s Republic of China
Herui Wei
Affiliation:
Department of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, People’s Republic of China
Aqian Song
Affiliation:
Department of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, People’s Republic of China
Yuanpeng Mao
Affiliation:
Department of Gastroenterology, Peking University Ditan Teaching Hospital, Beijing 100015, People’s Republic of China
Hao Bian
Affiliation:
Department of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, People’s Republic of China
Lingling He
Affiliation:
Department of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, People’s Republic of China
Fan Xiao
Affiliation:
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, People’s Republic of China Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, People’s Republic of China Beijing Institute of Infectious Diseases, Beijing 100015, People’s Republic of China National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, People’s Republic of China
Hongshan Wei*
Affiliation:
Department of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, People’s Republic of China Department of Gastroenterology, Peking University Ditan Teaching Hospital, Beijing 100015, People’s Republic of China
*
*Corresponding author: Hongshan Wei, email [email protected]
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Abstract

The associations between obesity and liver diseases are complex and diverse. To explore the causal relationships between obesity and liver diseases, we applied two-sample Mendelian randomisation (MR) and multivariable MR analysis. The data of exposures (BMI and WHRadjBMI) and outcomes (liver diseases and liver function biomarker) were obtained from the open genome-wide association study database. A two-sample MR study revealed that the genetically predicted BMI and WHRadjBMI were associated with non-alcoholic fatty liver disease, liver fibrosis and autoimmune hepatitis. Obesity was not associated with primary biliary cholangitis, liver failure, liver cell carcinoma, viral hepatitis and secondary malignant neoplasm of liver. A higher WHRadjBMI was associated with higher levels of biomarkers of lipid accumulation and metabolic disorders. These findings indicated independent causal roles of obesity in non-alcoholic fatty liver disease, liver fibrosis and impaired liver metabolic function rather than in viral or autoimmune liver disease.

Keywords

BMILiver diseaseNAFLDMendelian randomisationLiver fibrosis
Type
Research Article
Information
British Journal of Nutrition , Volume 132 , Issue 10 , 28 November 2024 , pp. 1403 - 1410
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

†

These authors contributed equally to this work.

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