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Differences in cholesterol and metabolic syndrome between bipolar disorder men with and without suicide attempts

Published online by Cambridge University Press:  24 June 2014

Bjanka Vuksan-Ćusa ,
Darko Marčinko ,
Sanea Nad  and
Miro Jakovljević
Bjanka Vuksan-Ćusa
Affiliation:
Department of Psychiatry, University Hospital Centre, Zagreb
Darko Marčinko
Affiliation:
Department of Psychiatry, General Hospital Virovitica, Virovitica, Croatia
Sanea Nad
Affiliation:
Department of Psychiatry, General Hospital Virovitica, Virovitica, Croatia
Miro Jakovljević
Affiliation:
Department of Psychiatry, General Hospital Virovitica, Virovitica, Croatia
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Abstract:

Patient with mental illnesses such as schizophrenia and bipolar disorder have an increased prevalence of metabolic syndrome (MetS) and its components compared to general population. Among psychiatric disorders, bipolar disorder ranks highest in suicidality with a relative risk ratio of completed suicide of about 25 compared to the general population. Regarding the biological hypotheses of suicidality, low blood cholesterol level has been extensively explored, although results are still conflicting. The aim of this study was to investigate whether there were differences in the serum cholesterol levels in hospitalized bipolar disorder men patients with history of suicide attempts (n= 20) and without suicide attempts (n= 20). Additionally, we investigated if there were differences in the prevalence of MetS according to NCEP ATP-III criteria in these two groups of patients. Results of the study indicated significantly lower serum cholesterol levels (P = 0.013) and triglyceride levels (P = 0.047), in the bipolar disorder men with suicide attempts in comparison to bipolar disorder men without suicide attempts. The overall prevalence of MetS was 11/40 (27.5%). On this particular sample it was higher in the non-attempters 8/20 (40.0%) than in attempters 3/20 (15.0%) bipolar men group, but without statistical significance. Lower concentrations of serum cholesterol might be useful biological markers of suicidality in men with bipolar disorder.

Type
Inpc Young Psychiatrists Programme
Information
Acta Neuropsychiatrica , Volume 21 , Issue S2: Special Issue: Abstracts of 49th Neuropsychiatric Pula Congress, 17-20 June 2009, Pula, Croatia , June 2009 , pp. 66 - 69
Copyright
Copyright © 2009 John Wiley & Sons A/S

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