Theologians often struggle to engage with scientific and technological proposals meaningfully in our contemporary context. This Element provides an introduction to the use of science fiction as a conversation partner for theological reflection, arguing that it shifts the science–religion dialogue away from propositional discourse in a more fruitful and imaginative direction. Science fiction will be presented as a mediator between theological and scientific disciplines and worldviews in the context of recent methodological debates. Several sections provide examples of theological engagement in relation to the themes of embodiment, human uniqueness, and disability, exploring relevant technologies such as mind-uploading, artificial intelligence, and virtual reality in dialogue with select works of science fiction.