The vivisection debates are an undervalued nexus for nineteenth-century beliefs about pain. Close readings of the Report of the 1876 Royal Commission on Vivisection reveal how conceptualisations of animal physiology, anaesthetic action, reflex responses, and pithing undermined direct correspondences between injury, pain, and expressions of suffering. The chapter then examines representations of graphic registration and recording technologies in laboratory handbooks. These devices seemed to offer a new, universal, wordless language, yet frequently conjured precisely those images of inscription, symbolism, and transliteration that many scientists were anxious to avoid. The chapter then presents animalographies and antivivisection poetry ‘spoken’ by animals. By purporting to access a more complete and individual non-human consciousness, these texts presented themselves as rivals to mechanical laboratory devices. Nevertheless, despite efforts to ‘listen’ to animals, antivivisectionists and experimental scientists encountered the same vexatious problem: Language, like pain, seemed equally troubled by the distance between signifier and signified.