This chapter focuses on ways to understand the Vietnam War through the operation of race in US interventions during the 1960s. As part of the inquiry, it examines friction between the United States and Panama in 1964 and the invasion of the Dominican Republic in 1965. France’s legacy in Vietnam and the US adaptation of French racialized colonial policies provide a backdrop for the war. The Cold War, rather than territorial annexation or economic exploitation, provided the chief rationale for the US presence in Vietnam and provided a path for particularly American forms of racism to emerge there and in areas of US domestic life that were affected by the conflict. In the interim, Vietnam served as a laboratory in which various theories about modernization and development were evaluated and carried out. The experiences of American minorities in the military are documented, including officials’ efforts to control dissidence in the ranks. African Americans, Native Americans, Mexican Americans, Puerto Ricans, and Asian Americans experienced the war in somewhat different ways, but all found themselves confronted by leading assumptions and practices about their minoritarian status. The war led many to see themselves as racially defined in a struggle whose costs were disproportionately borne by people of color amidst discrimination at home and by Vietnamese combatants abroad. As a result new sensibilities led to transformation in American civil society.