Given the mental health problems noted in schools as well as the high levels of trauma and disproportionate number of Black and Brown students referred for discipline or special education services, it is necessary to shift focus away from ameliorative change efforts. Transforming the culture and policies of schools – from punishment-based to relationship and trauma-responsive – is one way to increase opportunities for psychological and academic wellness while also disrupting the school-to-prison pipeline. A race-centered, trauma-responsive school approach that shifts attention away from a sole focus on individual-level (e.g., teaching mindfulness skills) and punishment-based (e.g., suspension) interventions often delivered to youth and instead proposes solutions at the level of the teacher, classroom, and school is presented in this chapter. This chapter provides an overview of the impacts and disparities in the prevalence of adverse childhood experiences, reviews the trauma-responsive school framework, and provides a case study of how race-centered, trauma-responsive schools can be used as a preventive strategy to reduce negative outcomes for children of the global majority.