Let $ H $ be a compact subgroup of a locally compact group $ G $ . We first investigate some (operator) (co)homological properties of the Fourier algebra $A(G/H)$ of the homogeneous space $G/H$ such as (operator) approximate biprojectivity and pseudo-contractibility. In particular, we show that $ A(G/H) $ is operator approximately biprojective if and only if $ G/H $ is discrete. We also show that $A(G/H)^{**}$ is boundedly approximately amenable if and only if G is compact and H is open. Finally, we consider the question of existence of weakly compact multipliers on $A(G/H)$ .

We characterize two important notions of amenability and compactness of a locally compact quantum group $\mathbb{G}$ in terms of certain homological properties. For this, we show that $\mathbb{G}$ is character amenable if and only if it is both amenable and co-amenable. We finally apply our results to Arens regularity problems of the quantum group algebra ${{L}^{1}}\left( \mathbb{G} \right)$. In particular, we improve an interesting result by Hu, Neufang, and Ruan.